Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976025413> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1976025413 endingPage "19" @default.
- W1976025413 startingPage "5" @default.
- W1976025413 abstract "Toxicity studies commonly include unavoidable environmental differences (experimental history) among test groups, such as chemical taste, odor and irritation. The influence of environmental variables on USEPA guideline neurotoxicity tests was evaluated using an environmental enrichment model. 6-week-old male Fischer 344 rats were housed for 13 weeks in pairs with access to an exercise wheel, trained to run on a rotating rod and handled frequently. Control animals were housed singly, lacked the exercise wheel and rotating rod training, and had only routine interaction with caretakers. At the end of 13 weeks, flash evoked potentials (FEPs), somatosensory evoked potentials (SEPs), auditory brainstem responses (ABRs), grip performance, motor activity (MA), elements of the functional observational battery (activity and reactivity to handling/restraint) and brain histopathology with glial fibrillary acidic protein immunohistochemistry (GFAP IHC) were evaluated. Animals from the enriched group demonstrated changes (P < 0.05) in FEPs, SEPs and grip performance. Enriched animals were more active and reactive to their surroundings, and were highly reactive to physical restraint. Control (unenriched) animals showed little to no exploratory behavior and were more tolerant of restraint. Differences in experimental history can be detected using elements of standard guideline tests and may confound interpretation of such data if not taken into consideration." @default.
- W1976025413 created "2016-06-24" @default.
- W1976025413 creator A5020214920 @default.
- W1976025413 creator A5047289160 @default.
- W1976025413 creator A5085699481 @default.
- W1976025413 creator A5090842068 @default.
- W1976025413 date "1993-01-01" @default.
- W1976025413 modified "2023-10-12" @default.
- W1976025413 title "Neurotoxicity screening methods are sensitive to experimental history" @default.
- W1976025413 cites W1979964492 @default.
- W1976025413 cites W1992559673 @default.
- W1976025413 cites W1997555493 @default.
- W1976025413 cites W2000243858 @default.
- W1976025413 cites W2007423323 @default.
- W1976025413 cites W2014501835 @default.
- W1976025413 cites W2037148849 @default.
- W1976025413 cites W2081113831 @default.
- W1976025413 cites W2088532584 @default.
- W1976025413 cites W2089239971 @default.
- W1976025413 cites W2111614347 @default.
- W1976025413 cites W4245757232 @default.
- W1976025413 cites W4253864180 @default.
- W1976025413 doi "https://doi.org/10.1016/0167-8760(93)90079-5" @default.
- W1976025413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8432680" @default.
- W1976025413 hasPublicationYear "1993" @default.
- W1976025413 type Work @default.
- W1976025413 sameAs 1976025413 @default.
- W1976025413 citedByCount "13" @default.
- W1976025413 countsByYear W19760254132016 @default.
- W1976025413 crossrefType "journal-article" @default.
- W1976025413 hasAuthorship W1976025413A5020214920 @default.
- W1976025413 hasAuthorship W1976025413A5047289160 @default.
- W1976025413 hasAuthorship W1976025413A5085699481 @default.
- W1976025413 hasAuthorship W1976025413A5090842068 @default.
- W1976025413 hasConcept C126322002 @default.
- W1976025413 hasConcept C15744967 @default.
- W1976025413 hasConcept C169760540 @default.
- W1976025413 hasConcept C172497186 @default.
- W1976025413 hasConcept C204232928 @default.
- W1976025413 hasConcept C2779491297 @default.
- W1976025413 hasConcept C2780495277 @default.
- W1976025413 hasConcept C29730261 @default.
- W1976025413 hasConcept C33070731 @default.
- W1976025413 hasConcept C42407357 @default.
- W1976025413 hasConcept C548259974 @default.
- W1976025413 hasConcept C71924100 @default.
- W1976025413 hasConcept C86803240 @default.
- W1976025413 hasConceptScore W1976025413C126322002 @default.
- W1976025413 hasConceptScore W1976025413C15744967 @default.
- W1976025413 hasConceptScore W1976025413C169760540 @default.
- W1976025413 hasConceptScore W1976025413C172497186 @default.
- W1976025413 hasConceptScore W1976025413C204232928 @default.
- W1976025413 hasConceptScore W1976025413C2779491297 @default.
- W1976025413 hasConceptScore W1976025413C2780495277 @default.
- W1976025413 hasConceptScore W1976025413C29730261 @default.
- W1976025413 hasConceptScore W1976025413C33070731 @default.
- W1976025413 hasConceptScore W1976025413C42407357 @default.
- W1976025413 hasConceptScore W1976025413C548259974 @default.
- W1976025413 hasConceptScore W1976025413C71924100 @default.
- W1976025413 hasConceptScore W1976025413C86803240 @default.
- W1976025413 hasIssue "1" @default.
- W1976025413 hasLocation W19760254131 @default.
- W1976025413 hasLocation W19760254132 @default.
- W1976025413 hasOpenAccess W1976025413 @default.
- W1976025413 hasPrimaryLocation W19760254131 @default.
- W1976025413 hasRelatedWork W180781197 @default.
- W1976025413 hasRelatedWork W2034337797 @default.
- W1976025413 hasRelatedWork W2042516624 @default.
- W1976025413 hasRelatedWork W2082645615 @default.
- W1976025413 hasRelatedWork W2137370585 @default.
- W1976025413 hasRelatedWork W2142797455 @default.
- W1976025413 hasRelatedWork W2182420774 @default.
- W1976025413 hasRelatedWork W2385141901 @default.
- W1976025413 hasRelatedWork W2396429908 @default.
- W1976025413 hasRelatedWork W2547701664 @default.
- W1976025413 hasVolume "14" @default.
- W1976025413 isParatext "false" @default.
- W1976025413 isRetracted "false" @default.
- W1976025413 magId "1976025413" @default.
- W1976025413 workType "article" @default.