Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976036102> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1976036102 abstract "The effects of temperature, pH, and apparatus design on in vitro drug release from a controlled-release vaginal device containing the prostaglandin, carboprost methyl, were investigated and a semi-automated drug release test was developed based on these studies. Accelerated drug release testing was found not to be feasible due to an apparent change in the release mechanism observed at 60 degrees C. At temperatures between 30-50 degrees C, Arrhenius behavior was observed with an activation energy of 18 kcal/mol. Drug release from the device was found to be insensitive to changes in pH. A commercially available auto-sampler was modified to enable unattended sampling over a 24-h test period using a cumulative drug release test based on the USP apparatus 1. In vivo drug release from the devices was monitored by calculating the amount released in 24 h in vivo from the difference between initial drug content and residual drug content in devices returned from the clinic. Results obtained via the in vitro drug release test compare favorably with the in vivo release results." @default.
- W1976036102 created "2016-06-24" @default.
- W1976036102 creator A5013738720 @default.
- W1976036102 creator A5031654679 @default.
- W1976036102 date "1985-07-01" @default.
- W1976036102 modified "2023-10-17" @default.
- W1976036102 title "Drug Release Testing of a Prostaglandin Containing Controlled-Release Vaginal Device: Development of a Semi-Automated Method" @default.
- W1976036102 cites W1919449728 @default.
- W1976036102 cites W1988138353 @default.
- W1976036102 cites W2042801031 @default.
- W1976036102 cites W2058918949 @default.
- W1976036102 cites W2070801021 @default.
- W1976036102 cites W2072488248 @default.
- W1976036102 cites W2080001672 @default.
- W1976036102 cites W2086492542 @default.
- W1976036102 cites W2123518900 @default.
- W1976036102 cites W2154894171 @default.
- W1976036102 cites W1983312146 @default.
- W1976036102 doi "https://doi.org/10.1002/jps.2600741014" @default.
- W1976036102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4078708" @default.
- W1976036102 hasPublicationYear "1985" @default.
- W1976036102 type Work @default.
- W1976036102 sameAs 1976036102 @default.
- W1976036102 citedByCount "5" @default.
- W1976036102 crossrefType "journal-article" @default.
- W1976036102 hasAuthorship W1976036102A5013738720 @default.
- W1976036102 hasAuthorship W1976036102A5031654679 @default.
- W1976036102 hasConcept C150903083 @default.
- W1976036102 hasConcept C163588942 @default.
- W1976036102 hasConcept C185592680 @default.
- W1976036102 hasConcept C202751555 @default.
- W1976036102 hasConcept C207001950 @default.
- W1976036102 hasConcept C2776711897 @default.
- W1976036102 hasConcept C2780035454 @default.
- W1976036102 hasConcept C43617362 @default.
- W1976036102 hasConcept C55493867 @default.
- W1976036102 hasConcept C71924100 @default.
- W1976036102 hasConcept C86803240 @default.
- W1976036102 hasConcept C98274493 @default.
- W1976036102 hasConceptScore W1976036102C150903083 @default.
- W1976036102 hasConceptScore W1976036102C163588942 @default.
- W1976036102 hasConceptScore W1976036102C185592680 @default.
- W1976036102 hasConceptScore W1976036102C202751555 @default.
- W1976036102 hasConceptScore W1976036102C207001950 @default.
- W1976036102 hasConceptScore W1976036102C2776711897 @default.
- W1976036102 hasConceptScore W1976036102C2780035454 @default.
- W1976036102 hasConceptScore W1976036102C43617362 @default.
- W1976036102 hasConceptScore W1976036102C55493867 @default.
- W1976036102 hasConceptScore W1976036102C71924100 @default.
- W1976036102 hasConceptScore W1976036102C86803240 @default.
- W1976036102 hasConceptScore W1976036102C98274493 @default.
- W1976036102 hasLocation W19760361021 @default.
- W1976036102 hasLocation W19760361022 @default.
- W1976036102 hasOpenAccess W1976036102 @default.
- W1976036102 hasPrimaryLocation W19760361021 @default.
- W1976036102 hasRelatedWork W1987369780 @default.
- W1976036102 hasRelatedWork W2030353236 @default.
- W1976036102 hasRelatedWork W2089102744 @default.
- W1976036102 hasRelatedWork W2104241359 @default.
- W1976036102 hasRelatedWork W2333021946 @default.
- W1976036102 hasRelatedWork W2438771022 @default.
- W1976036102 hasRelatedWork W2484274627 @default.
- W1976036102 hasRelatedWork W2791912237 @default.
- W1976036102 hasRelatedWork W36491935 @default.
- W1976036102 hasRelatedWork W4281768328 @default.
- W1976036102 isParatext "false" @default.
- W1976036102 isRetracted "false" @default.
- W1976036102 magId "1976036102" @default.
- W1976036102 workType "article" @default.