FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976036699> ?p ?o ?g. }

• W1976036699 abstract "Investigating the association between plasma levels of cytokines and chemokines, Selenoprotein S (SELS) gene variation and osteoarthritis (OA) subtypes.The genetics of osteoarthritis and progression (GARP) study consists of 191 sibling pairs with symptomatic OA at multiple joint sites. We have measured plasma levels of 17 cytokines and chemokines and genetic variation at the SELS gene.Nine out of 17 serum markers could be assessed quantitatively, whereas eight markers were assessed qualitatively. Principal component analysis (PCA) on the quantitatively assessed markers and serum high sensitive C-reactive protein (S-HsCRP) revealed that three components underlie 61% of the total plasma variation. Three single nucleotide polymorphisms (SNPs) in the SELS gene revealed four common haplotypes, one of which, GAG (frequency 3.5%) showed significant association to an anti-inflammatory (P=0.019) and acute phase related (P=0.036) component. OA subtype analysis showed that one component (mainly representing chemokine variation) was significantly associated to hand OA and disc degeneration (P=0.029 and P=0.010 respectively) as well as a physical component score (PCS) (P=0.042). The CRP related component also showed a strong association to the PCS (P=0.007). SELS haplotypes showed no association to OA subtypes in the GARP study.Genetic variation in the SELS gene associates to components representing inflammatory signaling. Another component, representing chemokine variation, showed association to hand OA and disc degeneration in the GARP study indicating chemokines may contribute to OA pathogenesis." @default.
• W1976036699 created "2016-06-24" @default.
• W1976036699 creator A5008911804 @default.
• W1976036699 creator A5024578345 @default.
• W1976036699 creator A5043817969 @default.
• W1976036699 creator A5044232630 @default.
• W1976036699 creator A5071478025 @default.
• W1976036699 creator A5078041038 @default.
• W1976036699 date "2009-05-01" @default.
• W1976036699 modified "2023-09-28" @default.
• W1976036699 title "The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA" @default.
• W1976036699 cites W1556150576 @default.
• W1976036699 cites W1896485613 @default.
• W1976036699 cites W1967057044 @default.
• W1976036699 cites W1968665346 @default.
• W1976036699 cites W2009524387 @default.
• W1976036699 cites W2010498861 @default.
• W1976036699 cites W2026245214 @default.
• W1976036699 cites W2030738459 @default.
• W1976036699 cites W2037755817 @default.
• W1976036699 cites W2044764337 @default.
• W1976036699 cites W2048630477 @default.
• W1976036699 cites W2058147305 @default.
• W1976036699 cites W2065563602 @default.
• W1976036699 cites W2066608222 @default.
• W1976036699 cites W2074587230 @default.
• W1976036699 cites W2080888774 @default.
• W1976036699 cites W2090593219 @default.
• W1976036699 cites W2096388167 @default.
• W1976036699 cites W2096564678 @default.
• W1976036699 cites W2101276590 @default.
• W1976036699 cites W2111747873 @default.
• W1976036699 cites W2126479977 @default.
• W1976036699 cites W2128759000 @default.
• W1976036699 cites W2150280564 @default.
• W1976036699 cites W2155702314 @default.
• W1976036699 cites W4232900352 @default.
• W1976036699 cites W4237427043 @default.
• W1976036699 doi "https://doi.org/10.1016/j.joca.2008.10.007" @default.
• W1976036699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19036615" @default.
• W1976036699 hasPublicationYear "2009" @default.
• W1976036699 type Work @default.
• W1976036699 sameAs 1976036699 @default.
• W1976036699 citedByCount "16" @default.
• W1976036699 countsByYear W19760366992012 @default.
• W1976036699 countsByYear W19760366992013 @default.
• W1976036699 countsByYear W19760366992014 @default.
• W1976036699 countsByYear W19760366992015 @default.
• W1976036699 countsByYear W19760366992017 @default.
• W1976036699 countsByYear W19760366992019 @default.
• W1976036699 countsByYear W19760366992020 @default.
• W1976036699 countsByYear W19760366992021 @default.
• W1976036699 countsByYear W19760366992022 @default.
• W1976036699 crossrefType "journal-article" @default.
• W1976036699 hasAuthorship W1976036699A5008911804 @default.
• W1976036699 hasAuthorship W1976036699A5024578345 @default.
• W1976036699 hasAuthorship W1976036699A5043817969 @default.
• W1976036699 hasAuthorship W1976036699A5044232630 @default.
• W1976036699 hasAuthorship W1976036699A5071478025 @default.
• W1976036699 hasAuthorship W1976036699A5078041038 @default.
• W1976036699 hasBestOaLocation W19760366991 @default.
• W1976036699 hasConcept C104317684 @default.
• W1976036699 hasConcept C13373296 @default.
• W1976036699 hasConcept C135763542 @default.
• W1976036699 hasConcept C153209595 @default.
• W1976036699 hasConcept C197754878 @default.
• W1976036699 hasConcept C203014093 @default.
• W1976036699 hasConcept C2776914184 @default.
• W1976036699 hasConcept C2780942790 @default.
• W1976036699 hasConcept C54355233 @default.
• W1976036699 hasConcept C68873052 @default.
• W1976036699 hasConcept C86803240 @default.
• W1976036699 hasConceptScore W1976036699C104317684 @default.
• W1976036699 hasConceptScore W1976036699C13373296 @default.
• W1976036699 hasConceptScore W1976036699C135763542 @default.
• W1976036699 hasConceptScore W1976036699C153209595 @default.
• W1976036699 hasConceptScore W1976036699C197754878 @default.
• W1976036699 hasConceptScore W1976036699C203014093 @default.
• W1976036699 hasConceptScore W1976036699C2776914184 @default.
• W1976036699 hasConceptScore W1976036699C2780942790 @default.
• W1976036699 hasConceptScore W1976036699C54355233 @default.
• W1976036699 hasConceptScore W1976036699C68873052 @default.
• W1976036699 hasConceptScore W1976036699C86803240 @default.
• W1976036699 hasLocation W19760366991 @default.
• W1976036699 hasLocation W19760366992 @default.
• W1976036699 hasOpenAccess W1976036699 @default.
• W1976036699 hasPrimaryLocation W19760366991 @default.
• W1976036699 hasRelatedWork W1968665346 @default.
• W1976036699 hasRelatedWork W1977292158 @default.
• W1976036699 hasRelatedWork W2009303892 @default.
• W1976036699 hasRelatedWork W2011956595 @default.
• W1976036699 hasRelatedWork W2016524890 @default.
• W1976036699 hasRelatedWork W2068924772 @default.
• W1976036699 hasRelatedWork W2075654568 @default.
• W1976036699 hasRelatedWork W2076883571 @default.
• W1976036699 hasRelatedWork W2080888774 @default.
• W1976036699 hasRelatedWork W2084296671 @default.
• W1976036699 hasRelatedWork W2107015180 @default.
• W1976036699 hasRelatedWork W2107158321 @default.
• W1976036699 hasRelatedWork W2111747873 @default.

• next