FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976044465> ?p ?o ?g. }

• W1976044465 endingPage "182" @default.
• W1976044465 startingPage "177" @default.
• W1976044465 abstract "Lipid phosphatase SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) plays an important role in the regulation of insulin signaling. In this report, we identified AS1938909, a novel small-molecule SHIP2 inhibitor. AS1938909 showed potent inhibition of SHIP2 (Ki = 0.44 μM) and significant selectivity over other related phosphatases. Further, AS1938909 increased Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes. Treatment of L6 myotubes with SHIP2 inhibitors for 48 h significantly induced expression of GLUT1 mRNA, but not that of GLUT4. These results suggest that pharmacological inhibition of SHIP2 activates glucose metabolism due, at least in part, to up-regulation of GLUT1 gene expression." @default.
• W1976044465 created "2016-06-24" @default.
• W1976044465 creator A5015150399 @default.
• W1976044465 creator A5024136589 @default.
• W1976044465 creator A5037429743 @default.
• W1976044465 creator A5038986805 @default.
• W1976044465 creator A5044782814 @default.
• W1976044465 creator A5067822373 @default.
• W1976044465 date "2010-09-01" @default.
• W1976044465 modified "2023-09-27" @default.
• W1976044465 title "Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes" @default.
• W1976044465 cites W1543180455 @default.
• W1976044465 cites W1770613978 @default.
• W1976044465 cites W1788773694 @default.
• W1976044465 cites W1977482532 @default.
• W1976044465 cites W1987488904 @default.
• W1976044465 cites W1990560955 @default.
• W1976044465 cites W2002123770 @default.
• W1976044465 cites W2018364757 @default.
• W1976044465 cites W2019332275 @default.
• W1976044465 cites W2027795688 @default.
• W1976044465 cites W2030406307 @default.
• W1976044465 cites W2037387433 @default.
• W1976044465 cites W2043965501 @default.
• W1976044465 cites W2057342074 @default.
• W1976044465 cites W2066862341 @default.
• W1976044465 cites W2123228319 @default.
• W1976044465 cites W2128842224 @default.
• W1976044465 cites W4231596891 @default.
• W1976044465 doi "https://doi.org/10.1016/j.ejphar.2010.06.002" @default.
• W1976044465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20558154" @default.
• W1976044465 hasPublicationYear "2010" @default.
• W1976044465 type Work @default.
• W1976044465 sameAs 1976044465 @default.
• W1976044465 citedByCount "22" @default.
• W1976044465 countsByYear W19760444652012 @default.
• W1976044465 countsByYear W19760444652013 @default.
• W1976044465 countsByYear W19760444652014 @default.
• W1976044465 countsByYear W19760444652017 @default.
• W1976044465 countsByYear W19760444652018 @default.
• W1976044465 countsByYear W19760444652019 @default.
• W1976044465 countsByYear W19760444652020 @default.
• W1976044465 countsByYear W19760444652021 @default.
• W1976044465 countsByYear W19760444652022 @default.
• W1976044465 crossrefType "journal-article" @default.
• W1976044465 hasAuthorship W1976044465A5015150399 @default.
• W1976044465 hasAuthorship W1976044465A5024136589 @default.
• W1976044465 hasAuthorship W1976044465A5037429743 @default.
• W1976044465 hasAuthorship W1976044465A5038986805 @default.
• W1976044465 hasAuthorship W1976044465A5044782814 @default.
• W1976044465 hasAuthorship W1976044465A5067822373 @default.
• W1976044465 hasConcept C104317684 @default.
• W1976044465 hasConcept C112446052 @default.
• W1976044465 hasConcept C11960822 @default.
• W1976044465 hasConcept C126322002 @default.
• W1976044465 hasConcept C134018914 @default.
• W1976044465 hasConcept C161573976 @default.
• W1976044465 hasConcept C17093226 @default.
• W1976044465 hasConcept C178666793 @default.
• W1976044465 hasConcept C185592680 @default.
• W1976044465 hasConcept C2776188179 @default.
• W1976044465 hasConcept C2777391703 @default.
• W1976044465 hasConcept C2777866211 @default.
• W1976044465 hasConcept C2777952866 @default.
• W1976044465 hasConcept C2779306644 @default.
• W1976044465 hasConcept C3763915 @default.
• W1976044465 hasConcept C55493867 @default.
• W1976044465 hasConcept C62231903 @default.
• W1976044465 hasConcept C71924100 @default.
• W1976044465 hasConcept C75217442 @default.
• W1976044465 hasConcept C86803240 @default.
• W1976044465 hasConceptScore W1976044465C104317684 @default.
• W1976044465 hasConceptScore W1976044465C112446052 @default.
• W1976044465 hasConceptScore W1976044465C11960822 @default.
• W1976044465 hasConceptScore W1976044465C126322002 @default.
• W1976044465 hasConceptScore W1976044465C134018914 @default.
• W1976044465 hasConceptScore W1976044465C161573976 @default.
• W1976044465 hasConceptScore W1976044465C17093226 @default.
• W1976044465 hasConceptScore W1976044465C178666793 @default.
• W1976044465 hasConceptScore W1976044465C185592680 @default.
• W1976044465 hasConceptScore W1976044465C2776188179 @default.
• W1976044465 hasConceptScore W1976044465C2777391703 @default.
• W1976044465 hasConceptScore W1976044465C2777866211 @default.
• W1976044465 hasConceptScore W1976044465C2777952866 @default.
• W1976044465 hasConceptScore W1976044465C2779306644 @default.
• W1976044465 hasConceptScore W1976044465C3763915 @default.
• W1976044465 hasConceptScore W1976044465C55493867 @default.
• W1976044465 hasConceptScore W1976044465C62231903 @default.
• W1976044465 hasConceptScore W1976044465C71924100 @default.
• W1976044465 hasConceptScore W1976044465C75217442 @default.
• W1976044465 hasConceptScore W1976044465C86803240 @default.
• W1976044465 hasIssue "1-3" @default.
• W1976044465 hasLocation W19760444651 @default.
• W1976044465 hasLocation W19760444652 @default.
• W1976044465 hasOpenAccess W1976044465 @default.
• W1976044465 hasPrimaryLocation W19760444651 @default.
• W1976044465 hasRelatedWork W1976044465 @default.
• W1976044465 hasRelatedWork W2069349303 @default.

• next