FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976058654> ?p ?o ?g. }

• W1976058654 abstract "Abstract Background The best strategy to protect individuals against meningococcal disease is to immunize against multiple serogroups. Immunogenicity, antibody persistence, and safety of the EU-licensed meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) were evaluated in healthy participants aged 11–55 years from the Philippines and Saudi Arabia. Methods In this phase IIb, open, controlled study, 500 participants were randomised (3:1) to receive one dose of MenACWY-TT or a licensed meningococcal polysaccharide vaccine (Men-PS). Functional antibody responses against meningococcal serogroups A, C, W-135, and Y were assessed by a serum bactericidal antibody assay using rabbit complement (rSBA) at Month 0, Month 1, Year 1, Year 2, and Year 3. Vaccine response was defined as an rSBA titre ≥32 at Month 1 in participants who were seronegative (rSBA titre <8) pre-vaccination and as at least a four-fold increase in titre in participants who were seropositive pre-vaccination. Solicited symptoms were recorded up to Day 4, safety outcomes up to Month 6, and serious adverse events related to vaccination up to Year 3. Results Pre-specified criteria for non-inferiority of MenACWY-TT versus Men-PS were met in terms of rSBA vaccine response and incidence of grade 3 general symptoms. At Month 1, 82.7%–96.3% of MenACWY-TT and 69.7%–91.7% in Men-PS recipients had a vaccine response for each serogroup. At Year 3, ≥99.1% and ≥92.9% of MenACWY-TT recipients retained rSBA titres ≥8 and ≥128, respectively, as compared to ≥86.7% and ≥80.0% in the Men-PS group. Both vaccines had a clinically acceptable safety profile, although injection site redness and swelling were more frequent in MenACWY-TT recipients. Conclusions These results suggest that MenACWY-TT could protect adolescents and adults against meningococcal disease up to three years post-vaccination. Trial registration This study is registered at http://www.clinicaltrials.gov/NCT00356369 ." @default.
• W1976058654 created "2016-06-24" @default.
• W1976058654 creator A5001803833 @default.
• W1976058654 creator A5025046013 @default.
• W1976058654 creator A5039254957 @default.
• W1976058654 creator A5042044329 @default.
• W1976058654 creator A5060209498 @default.
• W1976058654 creator A5060640852 @default.
• W1976058654 creator A5067123101 @default.
• W1976058654 date "2013-03-05" @default.
• W1976058654 modified "2023-10-07" @default.
• W1976058654 title "Immune response, antibody persistence, and safety of a single dose of the quadrivalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine in adolescents and adults: results of an open, randomised, controlled study" @default.
• W1976058654 cites W1575032160 @default.
• W1976058654 cites W1760572650 @default.
• W1976058654 cites W1912692997 @default.
• W1976058654 cites W1973149664 @default.
• W1976058654 cites W1976717129 @default.
• W1976058654 cites W1982921264 @default.
• W1976058654 cites W1986910419 @default.
• W1976058654 cites W1987029428 @default.
• W1976058654 cites W1989011168 @default.
• W1976058654 cites W1990910278 @default.
• W1976058654 cites W1992790837 @default.
• W1976058654 cites W2007023484 @default.
• W1976058654 cites W2009624085 @default.
• W1976058654 cites W2025502898 @default.
• W1976058654 cites W2033366028 @default.
• W1976058654 cites W2046127942 @default.
• W1976058654 cites W2057124618 @default.
• W1976058654 cites W2071305953 @default.
• W1976058654 cites W2082705433 @default.
• W1976058654 cites W2084125728 @default.
• W1976058654 cites W2093122797 @default.
• W1976058654 cites W2095551099 @default.
• W1976058654 cites W2095640451 @default.
• W1976058654 cites W2098570739 @default.
• W1976058654 cites W2106114549 @default.
• W1976058654 cites W2109381880 @default.
• W1976058654 cites W2115350923 @default.
• W1976058654 cites W2123686037 @default.
• W1976058654 cites W2130460485 @default.
• W1976058654 cites W2140617263 @default.
• W1976058654 cites W2141226147 @default.
• W1976058654 cites W2148938842 @default.
• W1976058654 cites W2154892242 @default.
• W1976058654 cites W2155611781 @default.
• W1976058654 cites W2160832246 @default.
• W1976058654 cites W2163457434 @default.
• W1976058654 cites W2163705357 @default.
• W1976058654 cites W2171028861 @default.
• W1976058654 cites W2171890935 @default.
• W1976058654 doi "https://doi.org/10.1186/1471-2334-13-116" @default.
• W1976058654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3599520" @default.
• W1976058654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23510357" @default.
• W1976058654 hasPublicationYear "2013" @default.
• W1976058654 type Work @default.
• W1976058654 sameAs 1976058654 @default.
• W1976058654 citedByCount "35" @default.
• W1976058654 countsByYear W19760586542013 @default.
• W1976058654 countsByYear W19760586542014 @default.
• W1976058654 countsByYear W19760586542015 @default.
• W1976058654 countsByYear W19760586542016 @default.
• W1976058654 countsByYear W19760586542017 @default.
• W1976058654 countsByYear W19760586542018 @default.
• W1976058654 countsByYear W19760586542019 @default.
• W1976058654 countsByYear W19760586542020 @default.
• W1976058654 countsByYear W19760586542021 @default.
• W1976058654 countsByYear W19760586542023 @default.
• W1976058654 crossrefType "journal-article" @default.
• W1976058654 hasAuthorship W1976058654A5001803833 @default.
• W1976058654 hasAuthorship W1976058654A5025046013 @default.
• W1976058654 hasAuthorship W1976058654A5039254957 @default.
• W1976058654 hasAuthorship W1976058654A5042044329 @default.
• W1976058654 hasAuthorship W1976058654A5060209498 @default.
• W1976058654 hasAuthorship W1976058654A5060640852 @default.
• W1976058654 hasAuthorship W1976058654A5067123101 @default.
• W1976058654 hasBestOaLocation W19760586541 @default.
• W1976058654 hasConcept C120665830 @default.
• W1976058654 hasConcept C121332964 @default.
• W1976058654 hasConcept C126322002 @default.
• W1976058654 hasConcept C159654299 @default.
• W1976058654 hasConcept C187212893 @default.
• W1976058654 hasConcept C197934379 @default.
• W1976058654 hasConcept C203014093 @default.
• W1976058654 hasConcept C22070199 @default.
• W1976058654 hasConcept C2776645655 @default.
• W1976058654 hasConcept C2777351567 @default.
• W1976058654 hasConcept C2778458888 @default.
• W1976058654 hasConcept C2779583294 @default.
• W1976058654 hasConcept C2779841045 @default.
• W1976058654 hasConcept C2780454893 @default.
• W1976058654 hasConcept C2780801004 @default.
• W1976058654 hasConcept C2780868878 @default.
• W1976058654 hasConcept C32611913 @default.
• W1976058654 hasConcept C523546767 @default.
• W1976058654 hasConcept C54355233 @default.
• W1976058654 hasConcept C61511704 @default.
• W1976058654 hasConcept C71924100 @default.
• W1976058654 hasConcept C86803240 @default.
• W1976058654 hasConceptScore W1976058654C120665830 @default.

• next