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• W1976069713 abstract "To evaluate determinants of elevated plasma atrial natriuretic factor levels in patients with hypertension, immunoreactive plasma atrial natriuretic factor in 54 normal subjects and 40 untreated hypertensive patients was compared with echocardiographic measurements of cardiac size, function and systemic hemodynamics. In normal subjects, plasma atrial natriuretic factor was related to age, systolic blood pressure and left atrial and ventricular chamber sizes, but only age and ventricular size were independent predictors. In untreated hypertensive patients, atrial natriuretic factor was directly related to age, atrial size, systolic pressure, peripheral resistance and ventricular systolic performance; age, atria[ size and peripheral resistance were independent predictors. Eight patients with elevated atrial natriuretic factor values (>25 fmo/ml) were significantly (p < 0.01) older and had greater atrial and ventricular size and higher systolic pressure and function than normal subjects or patients with normal natriuretic factor levels. Plasma atrial natriuretic factor was inversely related to peak diastolic filling rate in normal subjects (r = −0.59; p < 0.001), whereas it was positively related to the proportional contribution of atria[ systole to left ventricular filling in hypertensive patients (r = 0.77; p < 0.001). These findings suggest that in normal subjects, impairment of ventricular relaxation with age may contribute to atrial natriuretic factor secretion by increasing left atrial afterload; the correlation with left ventricular size may reflect physiologic fluctuations in plasma volume. In patients with uncomplicated hypertension, left atrial enlargement and consequent stronger atrial contraction contributed to increased atrial natriuretic factor release, whereas no independent relation existed with left ventricular hypertrophy or systolic function. Because ventricular relaxation was normal and ventricular size and systolic performance were increased in hypertensive patients with high atrial natriuretic factor levels, the observed increase in left atrial size and atrial contribution to ventricular filling might reflect a primary increase in venous return in this subset of hypertensive patients." @default.
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• W1976069713 date "1989-09-01" @default.
• W1976069713 modified "2023-10-16" @default.
• W1976069713 title "Plasma atrial natriuretic factor in essential hypertension: Relation to cardiac size, function and systemic hemodynamics" @default.
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• W1976069713 doi "https://doi.org/10.1016/0735-1097(89)90116-2" @default.
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