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• W1976072516 endingPage "1827" @default.
• W1976072516 startingPage "1811" @default.
• W1976072516 abstract "Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. In addition, abnormalities in inositol metabolism are associated with insulin resistance and with long term microvascular complications of diabetes, supporting a role of inositol or its derivatives in glucose metabolism. The aim of this review is to focus on the potential benefits of a dietary supplement of myo-inositol, by far the most common inositol isomer in foodstuffs, in human disorders associated with insulin resistance (polycystic ovary syndrome, gestational diabetes mellitus or metabolic syndrome) or in prevention or treatment of some diabetic complications (neuropathy, nephropathy, cataract). The relevance of such a nutritional strategy will be discussed for each context on the basis of the clinical and/or animal studies. The dietary sources of myo-inositol and its metabolism from its dietary uptake to its renal excretion will be also covered in this review. Finally, the actual insights into inositol insulin-sensitizing effects will be addressed and in particular the possible role of inositol glycans as insulin second messengers." @default.
• W1976072516 created "2016-06-24" @default.
• W1976072516 creator A5035380494 @default.
• W1976072516 creator A5088971388 @default.
• W1976072516 date "2013-10-01" @default.
• W1976072516 modified "2023-10-18" @default.
• W1976072516 title "Potential role and therapeutic interests of myo-inositol in metabolic diseases" @default.
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