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• W1976078168 abstract "ABSTRACT Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae . The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance mechanisms. The times above the MIC ( T >MIC) targets for stasis and 1- and 2-log reductions were 31%, 39%, and 42% for P. aeruginosa and 18%, 24%, and 27% for S. pneumoniae , respectively. The 1-log endpoint was achieved for strains with MICs as high as 16 μg/ml." @default.
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• W1976078168 date "2014-10-01" @default.
• W1976078168 modified "2023-10-16" @default.
• W1976078168 title "Impact of MIC Range for Pseudomonas aeruginosa and Streptococcus pneumoniae on the Ceftolozane <i>In Vivo</i> Pharmacokinetic/Pharmacodynamic Target" @default.
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• W1976078168 doi "https://doi.org/10.1128/aac.03572-14" @default.
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