Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976103487> ?p ?o ?g. }
- W1976103487 endingPage "G1117" @default.
- W1976103487 startingPage "G1106" @default.
- W1976103487 abstract "Chorda tympani denervation (CTD) of rats was earlier shown to result in loss of submandibular gland (SMG) weight (at only 1 wk) and in continued reduction in aquaporin 5 (AQP5) protein expression (until 4 wk), without affecting its mRNA synthesis (Li X, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K. Am J Physiol Gastrointest Liver Physiol 295: G112-G123, 2008). The present study indicated that despite elevation of bax, a proapoptosis protein, by CTD, the operation also increased the level of bcl-2, an antiapoptosis protein, in the SMG. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) showed no increase in the number of apoptotic cells in the SMG. CTD, however, induced strongly and transiently (at 1-3 days) the protein expression of LC3B-II, a marker protein of autophagosomes, suggesting that the reduction in the gland weight was due to onset of autophagy by CTD. Upon CTD, Lamp2, a lysosomal marker, gradually increased in amount, reaching a peak at the 14th day. Immunohistochemical analysis revealed an increase in the number of lysosome-like structures positive for both AQP5 and Lamp2 in the acinar cells of the SMG after CTD; similar changes were observed also for AQP5 and LC3Bs. These data suggest that AQP5 in the SMG entered autophagosomes and/or lysosomes for degradation upon CTD. In vitro AQP5-degrading activity was found in the SMG extracts, and such activity was shown to be increased by CTD. Inhibitor experiments implied cathepsins B and L to be candidate enzymes for this degradation under normal and CTD conditions, respectively." @default.
- W1976103487 created "2016-06-24" @default.
- W1976103487 creator A5000559103 @default.
- W1976103487 creator A5007292193 @default.
- W1976103487 creator A5011429891 @default.
- W1976103487 creator A5030605583 @default.
- W1976103487 creator A5035058787 @default.
- W1976103487 creator A5044962588 @default.
- W1976103487 creator A5053126990 @default.
- W1976103487 date "2010-11-01" @default.
- W1976103487 modified "2023-10-18" @default.
- W1976103487 title "Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation" @default.
- W1976103487 cites W1484492220 @default.
- W1976103487 cites W1592630118 @default.
- W1976103487 cites W1628370182 @default.
- W1976103487 cites W1644953918 @default.
- W1976103487 cites W1654921498 @default.
- W1976103487 cites W1964424355 @default.
- W1976103487 cites W1969900856 @default.
- W1976103487 cites W1969971796 @default.
- W1976103487 cites W2002335276 @default.
- W1976103487 cites W2011384708 @default.
- W1976103487 cites W2013029756 @default.
- W1976103487 cites W2013608912 @default.
- W1976103487 cites W2023905095 @default.
- W1976103487 cites W2025793732 @default.
- W1976103487 cites W2029360750 @default.
- W1976103487 cites W2035281754 @default.
- W1976103487 cites W2038858661 @default.
- W1976103487 cites W2041820145 @default.
- W1976103487 cites W2042000969 @default.
- W1976103487 cites W2042277624 @default.
- W1976103487 cites W2042279757 @default.
- W1976103487 cites W2045611996 @default.
- W1976103487 cites W2050487286 @default.
- W1976103487 cites W2052198628 @default.
- W1976103487 cites W2054176091 @default.
- W1976103487 cites W2063490374 @default.
- W1976103487 cites W2067701309 @default.
- W1976103487 cites W2071224279 @default.
- W1976103487 cites W2071488647 @default.
- W1976103487 cites W2073571990 @default.
- W1976103487 cites W2081401886 @default.
- W1976103487 cites W2082414348 @default.
- W1976103487 cites W2087199249 @default.
- W1976103487 cites W2090408121 @default.
- W1976103487 cites W2092435498 @default.
- W1976103487 cites W2093407677 @default.
- W1976103487 cites W2098738025 @default.
- W1976103487 cites W2100837269 @default.
- W1976103487 cites W2107285164 @default.
- W1976103487 cites W2120257894 @default.
- W1976103487 cites W2126806931 @default.
- W1976103487 cites W2127926936 @default.
- W1976103487 cites W2130866079 @default.
- W1976103487 cites W2131358644 @default.
- W1976103487 cites W2134979684 @default.
- W1976103487 cites W2147114301 @default.
- W1976103487 cites W2147219582 @default.
- W1976103487 cites W2147342303 @default.
- W1976103487 cites W2153758109 @default.
- W1976103487 cites W2154312242 @default.
- W1976103487 cites W2169356012 @default.
- W1976103487 cites W2169380117 @default.
- W1976103487 cites W2170562984 @default.
- W1976103487 cites W2238079773 @default.
- W1976103487 cites W2298860428 @default.
- W1976103487 cites W2328412164 @default.
- W1976103487 cites W2407808256 @default.
- W1976103487 doi "https://doi.org/10.1152/ajpgi.00194.2010" @default.
- W1976103487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20689061" @default.
- W1976103487 hasPublicationYear "2010" @default.
- W1976103487 type Work @default.
- W1976103487 sameAs 1976103487 @default.
- W1976103487 citedByCount "23" @default.
- W1976103487 countsByYear W19761034872012 @default.
- W1976103487 countsByYear W19761034872014 @default.
- W1976103487 countsByYear W19761034872015 @default.
- W1976103487 countsByYear W19761034872018 @default.
- W1976103487 countsByYear W19761034872020 @default.
- W1976103487 countsByYear W19761034872021 @default.
- W1976103487 countsByYear W19761034872022 @default.
- W1976103487 countsByYear W19761034872023 @default.
- W1976103487 crossrefType "journal-article" @default.
- W1976103487 hasAuthorship W1976103487A5000559103 @default.
- W1976103487 hasAuthorship W1976103487A5007292193 @default.
- W1976103487 hasAuthorship W1976103487A5011429891 @default.
- W1976103487 hasAuthorship W1976103487A5030605583 @default.
- W1976103487 hasAuthorship W1976103487A5035058787 @default.
- W1976103487 hasAuthorship W1976103487A5044962588 @default.
- W1976103487 hasAuthorship W1976103487A5053126990 @default.
- W1976103487 hasConcept C111368507 @default.
- W1976103487 hasConcept C125533998 @default.
- W1976103487 hasConcept C126322002 @default.
- W1976103487 hasConcept C127313418 @default.
- W1976103487 hasConcept C134018914 @default.
- W1976103487 hasConcept C181199279 @default.
- W1976103487 hasConcept C185592680 @default.