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- W1976112792 abstract "The action of pirenzepine as an antimuscarinic drug has been investigated on motor responses of muscle strips in the canine gall-bladder. Pirenzepine was further used to examine whether gall-bladder motor responses to synthetic sulphated cholecystokinin octapeptide (CCK-8) are sensitive to pirenzepine. Pirenzepine (10(-9)-10(-5) M) antagonized muscle contractions in response to acetylcholine (10(-9)-10(-2) M) and CCK-8 (10(-11)-10(-6) M) in a significant manner. These findings indicate that pirenzepine is a potent antagonist of two substances that are the principal contractile mediators of gall-bladder contraction and suggest that long-term administration of pirenzepine could contribute to stasis of the gall-bladder." @default.
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- W1976112792 date "1990-02-01" @default.
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- W1976112792 title "In-vitro Effect of Pirenzepine on Motility of Canine Gall-bladder" @default.
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- W1976112792 doi "https://doi.org/10.1111/j.2042-7158.1990.tb05360.x" @default.
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