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- W1976121808 abstract "To evaluate the efficacy and safety of intravenous cytarabine in the treatment of AIDS-associated progressive multifocal leukoencephalopathy (PML), we reviewed the charts of all human immunodeficiency virus-infected patients with PML who were seen during a 28-month period at our institution. Patients with biopsy-proven PML were offered therapy with intravenous cytarabine (2 mg/[kg ⋅ d] for 5 days every 4 weeks). The diagnosis of PML was histologically confirmed for 13 patients. The median CD4 cell count was 91 × 106/L. A median of three courses of cytarabine was administered to eight patients. Two patients developed mild drug-related toxicities. Clinical and/or radiological signs of improvement were observed for three patients treated with cytarabine; no signs of improvement were noted for the untreated patients. Median survival time after the diagnosis of PML was 102 days (range, 46–220 days) for patients who received cytarabine and 60 days (range, 28–72 days) for untreated patients matched for Karnofsky scores (P = .06, logrank test). Although cytarabine is well tolerated by patients with AIDS and PML, only modest short-term clinical improvement in the conditions of patients treated with the drug has been observed, with no significant impact on survival." @default.
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- W1976121808 date "1996-11-01" @default.
- W1976121808 modified "2023-10-17" @default.
- W1976121808 title "Cytarabine Therapy for Progressive Multifocal Leukoencephalopathy in Patients with AIDS" @default.
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- W1976121808 doi "https://doi.org/10.1093/clinids/23.5.1066" @default.
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