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• W1976130596 endingPage "606" @default.
• W1976130596 startingPage "595" @default.
• W1976130596 abstract "The glutamate transporters GLT-1 and GLAST are widely expressed in astrocytes in the brain where they fulfill important functions during glutamatergic neurotransmission. The present study examines their distribution in peripheral organs using in situ hybridization (ISH) and immunocytochemistry. GLAST was found to be more widely distributed than GLT-1. GLAST was expressed primarily in epithelial cells, cells of the macrophage-lineage, lymphocytes, fat cells, interstitial cells, and salivary gland acini. GLT-1 was primarily expressed in glandular tissue, including mammary gland, lacrimal gland, and ducts and acini in salivary glands, but also by perivenous hepatocytes and follicular dendritic cells in spleen and lymph nodes. The findings demonstrate that, although expressed by the same cells in the brain, these two glutamate transporters have different distribution patterns in peripheral tissues and that they fulfill glutamate transport functions apart from glutamatergic neurotransmission in these areas." @default.
• W1976130596 created "2016-06-24" @default.
• W1976130596 creator A5006874104 @default.
• W1976130596 creator A5078842111 @default.
• W1976130596 date "2006-07-26" @default.
• W1976130596 modified "2023-10-18" @default.
• W1976130596 title "Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs" @default.
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• W1976130596 doi "https://doi.org/10.1007/s00429-006-0109-x" @default.
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