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- W1976132189 abstract "Aim: To evaluate, in a model of diabetes+hypercaloric diet+ischemia–reperfusion (IR), if chronic therapy with MET improves cardiac mitochondrial function. Materials and methods: Goto–Kakizaki (GK) diabetic rats (fed with an hypercaloric diet between 2 and 6 months) were divided in 4 groups (n=10/group): A—GKHD control (no medication/no IR); B—MET control (Metformin 10 mg/kg/day between month 5 and 6/no IR); C—GKHD IR (as GKHD control and then IR); D—MET IR (as MET control and then IR). At 6 months, hearts were removed and submitted to 165 min perfusion (control) or 10 min perfusion +35 min ischemia +120 min reperfusion (IR). Mitochondrial parameters assessed were: oxidative stress (colorimetric thiobarbituric acid colorimetry test—TBARS), mitochondrial swelling and calcium uptake (fluorimetry). Results: MET-treated rats had significantly lower oxidative stress levels during IR (0.94±0.03 vs. 1.05±0.02 nmol TBARS/mg protein; p<0.05). MET-treated animals also showed a significant decrease in mitochondrial swelling in IR (57.7±2.3 vs. 68.1±1.8 arbitrary units—AU; p<0.05). MET therapy showed a trend towards an improvement in calcium uptake. Conclusion: In our model, MET improves cardiac mitochondrial function, due to less oxidative stress and better ischemia tolerance." @default.
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- W1976132189 date "2007-06-01" @default.
- W1976132189 modified "2023-09-27" @default.
- W1976132189 title "Effect of chronic metformin therapy in the mitochondrial function in an ex-vivo animal model of diabetes and hypercaloric diet submitted to global myocardial ischemia–reperfusion" @default.
- W1976132189 doi "https://doi.org/10.1016/j.yjmcc.2007.03.777" @default.
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