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- W1976133119 abstract "Determining the relationship between age and Alzheimer's disease (AD) presentation is important to improve understanding and provide better patient services.We used AD patient data (N = 7815) from the National Alzheimer Coordinating Center database and multinomial logistic regression to investigate presentation age and first cognitive/behavioral symptoms.The odds of having a nonmemory first cognitive symptom (including impairment in judgment and problem solving, language, and visuospatial function) increased with younger age (P < .001, all tests). Compared with apathy/withdrawal, the odds of having depression and other behavioral symptoms increased with younger age (P < .02, both tests), whereas the odds of having psychosis and no behavioral symptom increased with older age (P < .001, both tests).There is considerable heterogeneity in the first cognitive/behavioral symptoms experienced by AD patients. Proportions of these symptoms change with age with patients experiencing increasing nonmemory cognitive symptoms and more behavioral symptoms at younger ages." @default.
- W1976133119 created "2016-06-24" @default.
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- W1976133119 date "2015-04-24" @default.
- W1976133119 modified "2023-10-18" @default.
- W1976133119 title "Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset" @default.
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- W1976133119 doi "https://doi.org/10.1016/j.jalz.2014.12.007" @default.
- W1976133119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4619185" @default.
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