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• W1976144072 abstract "5-(2-Fluoroethyl)-2′-deoxyuridine (FEDU), its 2′-fluoroarabinofuranosyl analog (FEFAU) and the 2′-fluoroarabinofuranosyl analog (CEFAU) of the potent anti-herpesvirus compound 5-(2-chloroethyl)-2′-deoxyuridine (CEDU) were evaluated for activity against herpes simplex virus type 1 (HSV-1) and HSV-2 in vitro and in vivo. FEDU, FEFAU and CEFAU proved to be potent and selective anti-herpesvirus agents in vitro. Their potency is evident from their low minimum inhibitory concentrations for HSV-1 and HSV-2, and their selectivity is attested by the marginal inhibition of cell proliferation at relatively high concentrations, and by the high concentrations at which DNA-, RNA- or protein synthesis in normal uninfected host cells is inhibited. Their activity spectrum is broader than that of CEDU: in addition to being highly effective against HSV-1 replication, these derivatives, in particular FEFAU, inhibit HSV-2 replication at concentrations comparable to acyclovir (ACV). In the systemic and cutaneous HSV-1 infection models in mice, FEDU, FEFAU and CEFAU were markedly less potent than CEDU in suppressing the development of lesions and in reducing the mortality rate. In HSV-2 infections in mice and in guinea pigs FEDU, FEFAU and CEFAU were virtually ineffective. CEDU, however, exerted a protective effect in these animal models, albeit at relatively high concentrations." @default.
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• W1976144072 date "1987-06-01" @default.
• W1976144072 modified "2023-09-26" @default.
• W1976144072 title "In vitro and in vivo antiviral activity of 2′-fluorinated arabinosides of 5-(2-haloalkyl)uracil" @default.
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• W1976144072 doi "https://doi.org/10.1016/0166-3542(87)90011-8" @default.
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