Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976148924> ?p ?o ?g. }
- W1976148924 endingPage "32" @default.
- W1976148924 startingPage "23" @default.
- W1976148924 abstract "Background: The aim of this study was to relate the expression, analyzed by Western blot and immunohistochemistry, of several pro-inflammatory cytokines, including IL-1, IL-6 and TNF-α, with serum levels of prostate-specific antigen (PSA) in normal and pathologic (hyperplasia and cancer) prostate tissues to elucidate their possible role in tumor progression. We are also discussing the possible use of these cytokines as a potential therapeutic target. Methods: The study was carried out in 5 normal, 25 benign prostatic hyperplastic (BPH) and 17 cancerous human prostates (PC). Immunohistochemical and Western blot analysis were performed. Serum levels of PSA were assayed by an immulite autoanalyzer. Results: The most relevant results showed that in BPH, IL-1α, IL-6 and tumor necrosis factor (TNF) were only expressed in patients with PSA serum levels of 0–4 or 4–20 ng/ml, but not in the group >20 ng/ml. In PC these cytokines were only expressed in patients with PSA serum levels >4 ng/ml. Conclusions: In PC there was an association between the high expression of pro-inflammatory cytokines (TNFα, IL-6, IL-1), elevated serum levels of PSA and cancer progression. A better understanding of the biologic mechanism of this association may provide new targets for therapy in these patients." @default.
- W1976148924 created "2016-06-24" @default.
- W1976148924 creator A5003215527 @default.
- W1976148924 creator A5017371080 @default.
- W1976148924 creator A5027454749 @default.
- W1976148924 creator A5035200841 @default.
- W1976148924 creator A5038990077 @default.
- W1976148924 creator A5059643057 @default.
- W1976148924 creator A5061720379 @default.
- W1976148924 creator A5068691936 @default.
- W1976148924 creator A5073713205 @default.
- W1976148924 creator A5088768411 @default.
- W1976148924 date "2008-01-01" @default.
- W1976148924 modified "2023-10-18" @default.
- W1976148924 title "Pro-inflammatory cytokines and prostate-specific antigen in hyperplasia and human prostate cancer" @default.
- W1976148924 cites W1514081838 @default.
- W1976148924 cites W1594159276 @default.
- W1976148924 cites W1779691448 @default.
- W1976148924 cites W1967761338 @default.
- W1976148924 cites W1969888008 @default.
- W1976148924 cites W1971514924 @default.
- W1976148924 cites W1973040631 @default.
- W1976148924 cites W1978541038 @default.
- W1976148924 cites W1982261123 @default.
- W1976148924 cites W2001268142 @default.
- W1976148924 cites W2009017218 @default.
- W1976148924 cites W2012736444 @default.
- W1976148924 cites W2017607160 @default.
- W1976148924 cites W2018982924 @default.
- W1976148924 cites W2025937460 @default.
- W1976148924 cites W2027279302 @default.
- W1976148924 cites W2031687428 @default.
- W1976148924 cites W2037386042 @default.
- W1976148924 cites W2039428188 @default.
- W1976148924 cites W2041190672 @default.
- W1976148924 cites W2043622065 @default.
- W1976148924 cites W2057203537 @default.
- W1976148924 cites W2059724367 @default.
- W1976148924 cites W2070498132 @default.
- W1976148924 cites W2071230078 @default.
- W1976148924 cites W2075067618 @default.
- W1976148924 cites W2077246243 @default.
- W1976148924 cites W2096188348 @default.
- W1976148924 cites W2100531189 @default.
- W1976148924 cites W2145158999 @default.
- W1976148924 cites W2162465275 @default.
- W1976148924 cites W2335679869 @default.
- W1976148924 cites W2341444760 @default.
- W1976148924 cites W2389398856 @default.
- W1976148924 cites W4320801440 @default.
- W1976148924 doi "https://doi.org/10.1016/j.cdp.2008.02.007" @default.
- W1976148924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18400418" @default.
- W1976148924 hasPublicationYear "2008" @default.
- W1976148924 type Work @default.
- W1976148924 sameAs 1976148924 @default.
- W1976148924 citedByCount "64" @default.
- W1976148924 countsByYear W19761489242012 @default.
- W1976148924 countsByYear W19761489242013 @default.
- W1976148924 countsByYear W19761489242014 @default.
- W1976148924 countsByYear W19761489242015 @default.
- W1976148924 countsByYear W19761489242016 @default.
- W1976148924 countsByYear W19761489242017 @default.
- W1976148924 countsByYear W19761489242018 @default.
- W1976148924 countsByYear W19761489242019 @default.
- W1976148924 countsByYear W19761489242020 @default.
- W1976148924 countsByYear W19761489242021 @default.
- W1976148924 countsByYear W19761489242022 @default.
- W1976148924 countsByYear W19761489242023 @default.
- W1976148924 crossrefType "journal-article" @default.
- W1976148924 hasAuthorship W1976148924A5003215527 @default.
- W1976148924 hasAuthorship W1976148924A5017371080 @default.
- W1976148924 hasAuthorship W1976148924A5027454749 @default.
- W1976148924 hasAuthorship W1976148924A5035200841 @default.
- W1976148924 hasAuthorship W1976148924A5038990077 @default.
- W1976148924 hasAuthorship W1976148924A5059643057 @default.
- W1976148924 hasAuthorship W1976148924A5061720379 @default.
- W1976148924 hasAuthorship W1976148924A5068691936 @default.
- W1976148924 hasAuthorship W1976148924A5073713205 @default.
- W1976148924 hasAuthorship W1976148924A5088768411 @default.
- W1976148924 hasConcept C104317684 @default.
- W1976148924 hasConcept C121608353 @default.
- W1976148924 hasConcept C126322002 @default.
- W1976148924 hasConcept C142724271 @default.
- W1976148924 hasConcept C147483822 @default.
- W1976148924 hasConcept C164027704 @default.
- W1976148924 hasConcept C17991360 @default.
- W1976148924 hasConcept C203014093 @default.
- W1976148924 hasConcept C204232928 @default.
- W1976148924 hasConcept C2776235491 @default.
- W1976148924 hasConcept C2776415932 @default.
- W1976148924 hasConcept C2776914184 @default.
- W1976148924 hasConcept C2777562237 @default.
- W1976148924 hasConcept C2780192828 @default.
- W1976148924 hasConcept C2781406297 @default.
- W1976148924 hasConcept C55493867 @default.
- W1976148924 hasConcept C71924100 @default.
- W1976148924 hasConcept C86803240 @default.
- W1976148924 hasConcept C87874733 @default.