Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976159479> ?p ?o ?g. }
- W1976159479 endingPage "71" @default.
- W1976159479 startingPage "61" @default.
- W1976159479 abstract "How the number of docked vesicles is regulated is still unclear. Following chronic activity blockade the number of docked vesicles increases, providing a model through which to address this issue. We tested the hypotheses that the number of docked vesicles is regulated with the size of the terminal, and by the level of Rab3-interacting molecule 1/2 (RIM1/2). We immobilized mouse hippocampal slice cultures by high-pressure freezing after 3 days of tetrodotoxin treatment and analysed them by electron microscopy. The number of docked vesicles, the size of the active zones and the amount of GluA2 were increased after activity blockade. However, there was no modification of either the total number of synaptic vesicles or the area of presynaptic profiles. Surprisingly, immunocytochemistry showed no change in the mean level of RIM1/2 per terminal but its distribution was modified. Additionally, there was no modification of the mean frequency or amplitude of miniature excitatory postsynaptic currents, but the distribution of amplitudes was modified. These results indicate a specific homeostatic regulation of the synaptic junction. The number of docked vesicles does not seem to be regulated by the amount of RIM1/2. The modification of the distribution, but not the amount, of RIM1/2 may explain the contradiction between the morphological and electrophysiological findings." @default.
- W1976159479 created "2016-06-24" @default.
- W1976159479 creator A5007391820 @default.
- W1976159479 creator A5026816664 @default.
- W1976159479 creator A5060920591 @default.
- W1976159479 creator A5076195816 @default.
- W1976159479 date "2013-10-25" @default.
- W1976159479 modified "2023-09-26" @default.
- W1976159479 title "Adaptive and non-adaptive changes in activity-deprived presynaptic terminals" @default.
- W1976159479 cites W1514853588 @default.
- W1976159479 cites W1517253433 @default.
- W1976159479 cites W1597908762 @default.
- W1976159479 cites W1756593109 @default.
- W1976159479 cites W1964189494 @default.
- W1976159479 cites W1966020111 @default.
- W1976159479 cites W1977423896 @default.
- W1976159479 cites W1982016364 @default.
- W1976159479 cites W1999842111 @default.
- W1976159479 cites W2002352665 @default.
- W1976159479 cites W2004767225 @default.
- W1976159479 cites W2011046807 @default.
- W1976159479 cites W2031492629 @default.
- W1976159479 cites W2031522258 @default.
- W1976159479 cites W2032609932 @default.
- W1976159479 cites W2033946734 @default.
- W1976159479 cites W2041624665 @default.
- W1976159479 cites W2041733763 @default.
- W1976159479 cites W2053129791 @default.
- W1976159479 cites W2064268683 @default.
- W1976159479 cites W2077005039 @default.
- W1976159479 cites W2079054696 @default.
- W1976159479 cites W2080611091 @default.
- W1976159479 cites W2081259067 @default.
- W1976159479 cites W2082372907 @default.
- W1976159479 cites W2084621903 @default.
- W1976159479 cites W2093490616 @default.
- W1976159479 cites W2093514926 @default.
- W1976159479 cites W2094202922 @default.
- W1976159479 cites W2129766810 @default.
- W1976159479 cites W2142784661 @default.
- W1976159479 cites W2151624292 @default.
- W1976159479 cites W2169980562 @default.
- W1976159479 doi "https://doi.org/10.1111/ejn.12399" @default.
- W1976159479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24164653" @default.
- W1976159479 hasPublicationYear "2013" @default.
- W1976159479 type Work @default.
- W1976159479 sameAs 1976159479 @default.
- W1976159479 citedByCount "2" @default.
- W1976159479 countsByYear W19761594792018 @default.
- W1976159479 countsByYear W19761594792022 @default.
- W1976159479 crossrefType "journal-article" @default.
- W1976159479 hasAuthorship W1976159479A5007391820 @default.
- W1976159479 hasAuthorship W1976159479A5026816664 @default.
- W1976159479 hasAuthorship W1976159479A5060920591 @default.
- W1976159479 hasAuthorship W1976159479A5076195816 @default.
- W1976159479 hasConcept C112592302 @default.
- W1976159479 hasConcept C12554922 @default.
- W1976159479 hasConcept C130316041 @default.
- W1976159479 hasConcept C148762608 @default.
- W1976159479 hasConcept C148785051 @default.
- W1976159479 hasConcept C169760540 @default.
- W1976159479 hasConcept C170493617 @default.
- W1976159479 hasConcept C17077164 @default.
- W1976159479 hasConcept C185592680 @default.
- W1976159479 hasConcept C197341189 @default.
- W1976159479 hasConcept C2776741303 @default.
- W1976159479 hasConcept C2910581834 @default.
- W1976159479 hasConcept C41625074 @default.
- W1976159479 hasConcept C55493867 @default.
- W1976159479 hasConcept C86803240 @default.
- W1976159479 hasConcept C95444343 @default.
- W1976159479 hasConceptScore W1976159479C112592302 @default.
- W1976159479 hasConceptScore W1976159479C12554922 @default.
- W1976159479 hasConceptScore W1976159479C130316041 @default.
- W1976159479 hasConceptScore W1976159479C148762608 @default.
- W1976159479 hasConceptScore W1976159479C148785051 @default.
- W1976159479 hasConceptScore W1976159479C169760540 @default.
- W1976159479 hasConceptScore W1976159479C170493617 @default.
- W1976159479 hasConceptScore W1976159479C17077164 @default.
- W1976159479 hasConceptScore W1976159479C185592680 @default.
- W1976159479 hasConceptScore W1976159479C197341189 @default.
- W1976159479 hasConceptScore W1976159479C2776741303 @default.
- W1976159479 hasConceptScore W1976159479C2910581834 @default.
- W1976159479 hasConceptScore W1976159479C41625074 @default.
- W1976159479 hasConceptScore W1976159479C55493867 @default.
- W1976159479 hasConceptScore W1976159479C86803240 @default.
- W1976159479 hasConceptScore W1976159479C95444343 @default.
- W1976159479 hasFunder F4320320883 @default.
- W1976159479 hasIssue "1" @default.
- W1976159479 hasLocation W19761594791 @default.
- W1976159479 hasLocation W19761594792 @default.
- W1976159479 hasOpenAccess W1976159479 @default.
- W1976159479 hasPrimaryLocation W19761594791 @default.
- W1976159479 hasRelatedWork W1976159479 @default.
- W1976159479 hasRelatedWork W2010044589 @default.
- W1976159479 hasRelatedWork W2069362932 @default.
- W1976159479 hasRelatedWork W2085534172 @default.
- W1976159479 hasRelatedWork W2127023470 @default.