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- W1976162551 abstract "<i>Introduction:</i> Glutathione S-transferases have been implicated in the development of bladder cancer (BC). We investigated the genotype and expression of glutathione S-transferase-mu <i>(GSTM1)</i> and glutathione S-transferase-theta <i>(GSTT1)</i> in BC tissue specimens. <i>Materials and Methods:</i> Tumor samples and matched normal mucosae were obtained from 34 patients. Genomic DNA was used to analyze <i>GSTM1</i> and <i>GSTT1</i> genotypes using multiplex polymerase chain reaction. <i>GSTM1</i> and <i>GSTT1</i> mRNA levels were measured using real-time reverse transcriptase polymerase chain reaction. <i>Results:</i><i>GSTM1</i> mRNA expression was lower in tumor tissues than in matched normal bladder mucosae, whereas <i>GSTT1</i> mRNA expression was significantly higher. <i>GSTT1</i> mRNA expression was higher in muscle-invasive BC and high-grade cancers than in non-muscle-invasive BC and lower-grade tumors. <i>Conclusions:</i><i>GSTT1</i> is correlated with characteristics of aggressive BC. <i>GSTT1</i> may play an important role in tumorigenesis and disease progression in patients with BC." @default.
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- W1976162551 date "2010-11-16" @default.
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- W1976162551 title "GSTT1: A Marker of the Aggressiveness of Bladder Cancer" @default.
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- W1976162551 doi "https://doi.org/10.1159/000321689" @default.
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