Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976171346> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1976171346 endingPage "899" @default.
- W1976171346 startingPage "S" @default.
- W1976171346 abstract "We showed that glucose absorption is accelerated in the proximal intestine of morbidly obese humans, associated with increased expression of sodium dependent glucose co-transporter 1 (SGLT1), an altered incretin profile, hyperinsulinemia and hyperglycemia. This study aimed to examine the effects of energy restriction on glucose absorption, expression of intestinal glucose transporters and sweet taste receptors (STR), incretin hormone responses and glycemia in the morbidly obese. Methods: 10 non-diabetic, morbidly obese subjects (2M:8F; 45±3yrs, BMI: 46±3kg/m2) were studied before and after a 2-week VLCD (750kcal/day). On each occasion, endoscopic duodenal biopsies were collected before and after intraduodenal glucose infusion (30g glucose over 30 min, with 3g 3-O-methylglucose (3-OMG) to estimate glucose absorption). Blood glucose and plasma concentrations of 3-OMG, glucosedependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and insulin were measured over 240 min. Absolute expression of SGLT-1, GLUT2 and STR (T1R2) transcripts was quantified by PCR. Results After 2 weeks of VLCD, body weight (-5.6±0.5kg, P<0.001), HbA1c (-0.32±0.08%, P=0.001), fasting blood glucose (-0.5±0.1mmol/L, P=0.02) and fasting expression of T1R2 (-54±22%, P=0.03), SGLT1 (-30±7%, P=0.004) and GLUT2 (-50±15%, P=0.008) were lower than at baseline. Prior to VLCD, intra-duodenal glucose had no impact onT1R2, SGLT-1 and GLUT2 expression, but after VLCD, intra-duodenal glucose stimulated increased expression of T1R2 (45±30%, P=0.03) and GLUT2 (57±14%, P=0.003). The blood glucose (P=0.002), plasma GIP (P=0.03) and plasma insulin (P=0.002) responses to intra-duodenal glucose were all reduced after VLCD, while plasma 3-OMG and GLP-1 concentrations were unchanged. CONCLUSIONS: The improvement in glycemic control after short-term VLCD in morbid obesity is most likely mediated by reduced insulin resistance from weight loss, but not via a reduction in intestinal glucose absorption or an increased incretin response. Although VCLD reduces the fasting expression of both STR and glucose transporters, these increase rapidly on exposure to glucose. Further studies with inhibitors of STR and/or glucose transporters are warranted to determine whether the changes in receptor expressional dynamics are responsible for the observed incretin responses." @default.
- W1976171346 created "2016-06-24" @default.
- W1976171346 creator A5000624891 @default.
- W1976171346 creator A5005301153 @default.
- W1976171346 creator A5007196114 @default.
- W1976171346 creator A5014762373 @default.
- W1976171346 creator A5016315222 @default.
- W1976171346 creator A5028223956 @default.
- W1976171346 creator A5036647290 @default.
- W1976171346 creator A5043684877 @default.
- W1976171346 creator A5045251725 @default.
- W1976171346 creator A5053957565 @default.
- W1976171346 creator A5071588452 @default.
- W1976171346 creator A5074230650 @default.
- W1976171346 creator A5091339351 @default.
- W1976171346 date "2014-05-01" @default.
- W1976171346 modified "2023-09-26" @default.
- W1976171346 title "Tu2013 A Short Bowel Syndrome Rodent Model Mimicking the Human Pathology Results in Increased AgRP/NPY and Decreased POMC/TRH Expression in the Hypothalamus" @default.
- W1976171346 doi "https://doi.org/10.1016/s0016-5085(14)63267-4" @default.
- W1976171346 hasPublicationYear "2014" @default.
- W1976171346 type Work @default.
- W1976171346 sameAs 1976171346 @default.
- W1976171346 citedByCount "0" @default.
- W1976171346 crossrefType "journal-article" @default.
- W1976171346 hasAuthorship W1976171346A5000624891 @default.
- W1976171346 hasAuthorship W1976171346A5005301153 @default.
- W1976171346 hasAuthorship W1976171346A5007196114 @default.
- W1976171346 hasAuthorship W1976171346A5014762373 @default.
- W1976171346 hasAuthorship W1976171346A5016315222 @default.
- W1976171346 hasAuthorship W1976171346A5028223956 @default.
- W1976171346 hasAuthorship W1976171346A5036647290 @default.
- W1976171346 hasAuthorship W1976171346A5043684877 @default.
- W1976171346 hasAuthorship W1976171346A5045251725 @default.
- W1976171346 hasAuthorship W1976171346A5053957565 @default.
- W1976171346 hasAuthorship W1976171346A5071588452 @default.
- W1976171346 hasAuthorship W1976171346A5074230650 @default.
- W1976171346 hasAuthorship W1976171346A5091339351 @default.
- W1976171346 hasConcept C126322002 @default.
- W1976171346 hasConcept C134018914 @default.
- W1976171346 hasConcept C161573976 @default.
- W1976171346 hasConcept C2776398474 @default.
- W1976171346 hasConcept C2777180221 @default.
- W1976171346 hasConcept C2777391703 @default.
- W1976171346 hasConcept C2777901630 @default.
- W1976171346 hasConcept C2778881409 @default.
- W1976171346 hasConcept C2779306644 @default.
- W1976171346 hasConcept C2780988686 @default.
- W1976171346 hasConcept C3018667095 @default.
- W1976171346 hasConcept C555293320 @default.
- W1976171346 hasConcept C71924100 @default.
- W1976171346 hasConceptScore W1976171346C126322002 @default.
- W1976171346 hasConceptScore W1976171346C134018914 @default.
- W1976171346 hasConceptScore W1976171346C161573976 @default.
- W1976171346 hasConceptScore W1976171346C2776398474 @default.
- W1976171346 hasConceptScore W1976171346C2777180221 @default.
- W1976171346 hasConceptScore W1976171346C2777391703 @default.
- W1976171346 hasConceptScore W1976171346C2777901630 @default.
- W1976171346 hasConceptScore W1976171346C2778881409 @default.
- W1976171346 hasConceptScore W1976171346C2779306644 @default.
- W1976171346 hasConceptScore W1976171346C2780988686 @default.
- W1976171346 hasConceptScore W1976171346C3018667095 @default.
- W1976171346 hasConceptScore W1976171346C555293320 @default.
- W1976171346 hasConceptScore W1976171346C71924100 @default.
- W1976171346 hasIssue "5" @default.
- W1976171346 hasLocation W19761713461 @default.
- W1976171346 hasOpenAccess W1976171346 @default.
- W1976171346 hasPrimaryLocation W19761713461 @default.
- W1976171346 hasRelatedWork W1801486040 @default.
- W1976171346 hasRelatedWork W1966237803 @default.
- W1976171346 hasRelatedWork W1978164012 @default.
- W1976171346 hasRelatedWork W1978577632 @default.
- W1976171346 hasRelatedWork W1994121001 @default.
- W1976171346 hasRelatedWork W1997774629 @default.
- W1976171346 hasRelatedWork W2007621981 @default.
- W1976171346 hasRelatedWork W2011297546 @default.
- W1976171346 hasRelatedWork W2016648334 @default.
- W1976171346 hasRelatedWork W2024377424 @default.
- W1976171346 hasRelatedWork W2029050948 @default.
- W1976171346 hasRelatedWork W2074355393 @default.
- W1976171346 hasRelatedWork W2087175029 @default.
- W1976171346 hasRelatedWork W2094128609 @default.
- W1976171346 hasRelatedWork W2100968639 @default.
- W1976171346 hasRelatedWork W2113983269 @default.
- W1976171346 hasRelatedWork W2154044488 @default.
- W1976171346 hasRelatedWork W2351259889 @default.
- W1976171346 hasRelatedWork W2763160115 @default.
- W1976171346 hasRelatedWork W2914038701 @default.
- W1976171346 hasVolume "146" @default.
- W1976171346 isParatext "false" @default.
- W1976171346 isRetracted "false" @default.
- W1976171346 magId "1976171346" @default.
- W1976171346 workType "article" @default.