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• W1976173668 abstract "In the present study we have evaluated the antigenotoxic effects of Farnesol (FL) a 15-carbon isoprenoid alcohol against benzo (a) pyrene [B(a)P] (125 mg kg(- 1).b.wt oral) induced toxicity. B(a)P administration lead to significant induction in Cytochrome P450 (CYP) content and aryl hydrocarbon hydrolase (AHH) activity (p < 0.001), DNA strand breaks and DNA adducts (p < 0.001) formation. FL was shown to suppress the activities of both CYP and AHH (p < 0.005) in modulator groups. FL pretreatment significantly (p < 0.001) restored depleted levels of reduced glutathione (GSH), quinone reductase (QR) and glutathione -S-transferase (GST). A simultaneous significant and at both the doses reduction was seen in DNA strand breaks and in in-vivo DNA adducts formation (p < 0.005), which gives some insight on restoration of DNA integrity. The results support the protective nature of FL. Hence present data supports FL as a future drug to preclude B (a) P induced toxicity." @default.
• W1976173668 created "2016-06-24" @default.
• W1976173668 creator A5021115694 @default.
• W1976173668 creator A5074558908 @default.
• W1976173668 date "2008-01-01" @default.
• W1976173668 modified "2023-10-02" @default.
• W1976173668 title "Benzo(a)pyrene-induced genotoxicity: Attenuation by farnesol in a mouse model" @default.
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• W1976173668 doi "https://doi.org/10.1080/14756360701448768" @default.
• W1976173668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18618320" @default.
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