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- W1976175041 abstract "α -Asarone is the major therapeutical constituent of Acorus tatarinowii Schott. In this study, the potential protective effects of α -asarone against endothelial cell injury induced by angiotensin II were investigated in vitro . The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated with α -asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang II (0.1 µmol/L) for 24 h. Intracellular nitric oxide (NO) and reactive oxygen species (ROS) were detected by fluorescent dyes, and phosphorylation of endothelial nitric oxide synthase (eNOS) at<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msup><mml:mrow><mml:mtext>Ser</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1177</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>was determined by Western blotting. α -Asarone dose-dependently mitigated the Ang II-induced intracellular NO reduction (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>versus model) and ROS production (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>versus model). Furthermore, eNOS phosphorylation (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msup><mml:mrow><mml:mtext>Ser</mml:mtext></mml:mrow><mml:mrow><mml:mtext>1177</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>) by acetylcholine was significantly inhibited by Ang II, while pretreatment for 1 h with α -asarone partially prevented this effect (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>versus model). Additionally, cell viability determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (105~114.5% versus control,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.05</mml:mn></mml:math>) was not affected after 24 h of incubation with α -asarone at 1–100 µmol/L. Therefore, α -asarone protects against Ang II-mediated damage of endothelial cells and may be developed to prevent injury to cardiovascular tissues." @default.
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- W1976175041 date "2014-01-01" @default.
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- W1976175041 title "Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II" @default.
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- W1976175041 doi "https://doi.org/10.1155/2014/682041" @default.
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