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- W1976177535 endingPage "1326" @default.
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- W1976177535 abstract "The tissue-specific gene expression at the brain microvasculature, which forms the blood–brain barrier (BBB) in vivo, can be elucidated with a brain vascular genomics program, which starts with the isolation of gene products derived from purified brain microvessels. Genes commonly expressed in peripheral organs are subtracted with the suppression subtractive hybridization method using driver cDNA produced from a pool of rat liver/kidney–derived poly A+RNA. From a screen of 480 clones in the subtracted tester cDNA library, 156 clones were sequenced. The clones fell into 3 groups: known genes (51%), rat expressed sequence tags (31%), and novel rat genes not found in databases (18%). The known genes could be categorized into families of common function including vascular remodeling, signal transduction, transcription factors, biologic transport, vascular amyloid, hemostasis, myelin, lipids, secretion, cytoskeleton, and junctional complexes. Brain vascular genomics, or BBB genomics, allows for an accelerated discovery of the gene families that are differentially expressed at the microvasculature in brain." @default.
- W1976177535 created "2016-06-24" @default.
- W1976177535 creator A5000308279 @default.
- W1976177535 creator A5011011962 @default.
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- W1976177535 date "2002-11-01" @default.
- W1976177535 modified "2023-10-11" @default.
- W1976177535 title "Rat Blood–Brain Barrier Genomics. II" @default.
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- W1976177535 doi "https://doi.org/10.1097/01.wcb.0000040944.89393.0f" @default.
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