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- W1976179991 endingPage "285" @default.
- W1976179991 startingPage "273" @default.
- W1976179991 abstract "Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described." @default.
- W1976179991 created "2016-06-24" @default.
- W1976179991 creator A5000449811 @default.
- W1976179991 creator A5061597843 @default.
- W1976179991 creator A5071421445 @default.
- W1976179991 creator A5082002978 @default.
- W1976179991 date "2014-03-11" @default.
- W1976179991 modified "2023-10-02" @default.
- W1976179991 title "Antimutagenic compounds and their possible mechanisms of action" @default.
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