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- W1976197487 abstract "Defining the genetic basis of essential hypertension is most informative when the blood pressure regulation is correlated with physiologic mechanisms, e.g., responses of the renin–angiotensin aldosterone system (RAAS) in hypertensive subjects. The aldosterone response to angiotensin II (Ang II) on a low salt diet is influenced by gender, plasma renin activity, and most significantly, familial resemblance, but only in males and in post-menopausal females. There is familial aggregation of low-renin hypertension, no association with candidate genes of the RAAS, but, a highly significant association with polymorphisms in the alpha-adducin gene. Finally, angiotensinogen (AGT) genotype effects renal and adrenal responses to Ang II in patients with hypertension. These results strongly suggest that in contrast to population-based studies that use hypertension as the phenotype, classifying patients by the variability in physiologic, mechanistic traits enhances the probability of identifying the genetic factors influencing a rise in blood pressure." @default.
- W1976197487 created "2016-06-24" @default.
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- W1976197487 date "2004-03-01" @default.
- W1976197487 modified "2023-09-23" @default.
- W1976197487 title "Genetic factors associated with volume-sensitive hypertension" @default.
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- W1976197487 doi "https://doi.org/10.1016/j.mce.2003.10.007" @default.
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