FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976200636> ?p ?o ?g. }

• W1976200636 endingPage "762" @default.
• W1976200636 startingPage "762" @default.
• W1976200636 abstract "Proteomic profiling has emerged as a useful tool for identifying tissue alterations in disease states including malignant transformation. The aim of this study was to reveal expression profiles associated with the highly motile/invasive ovarian cancer cell phenotype. Six ovarian cancer cell lines were subjected to proteomic characterization using multidimensional protein identification technology (MudPIT), and evaluated for their motile/invasive behavior, so that these parameters could be compared. Within whole cell extracts of the ovarian cancer cells, MudPIT identified proteins that mapped to 2245 unique genes. Western blot analysis for selected proteins confirmed the expression profiles revealed by MudPIT, demonstrating the fidelity of this high-throughput analysis. Unsupervised cluster analysis partitioned the cell lines in a manner that reflected their motile/invasive capacity. A comparison of protein expression profiles between cell lines of high (group 1) versus low (group 2) motile/invasive capacity revealed 300 proteins that were differentially expressed, of which 196 proteins were significantly upregulated in group 1. Protein network and KEGG pathway analysis indicated a functional interplay between proteins up-regulated in group 1 cells, with increased expression of several key members of the actin cytoskeleton, extracellular matrix (ECM) and focal adhesion pathways. These proteomic expression profiles can be utilized to distinguish highly motile, aggressive ovarian cancer cells from lesser invasive ones, and could prove to be essential in the development of more effective strategies that target pivotal cell signaling pathways used by cancer cells during local invasion and distant metastasis." @default.
• W1976200636 created "2016-06-24" @default.
• W1976200636 creator A5011029168 @default.
• W1976200636 creator A5025268507 @default.
• W1976200636 creator A5041682013 @default.
• W1976200636 creator A5051341401 @default.
• W1976200636 creator A5055656807 @default.
• W1976200636 creator A5069365222 @default.
• W1976200636 creator A5081952675 @default.
• W1976200636 creator A5091039507 @default.
• W1976200636 date "2008-01-01" @default.
• W1976200636 modified "2023-10-11" @default.
• W1976200636 title "Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT)" @default.
• W1976200636 cites W1542673196 @default.
• W1976200636 cites W158416054 @default.
• W1976200636 cites W1597678601 @default.
• W1976200636 cites W1969782660 @default.
• W1976200636 cites W1975520857 @default.
• W1976200636 cites W1978162947 @default.
• W1976200636 cites W1985497018 @default.
• W1976200636 cites W1987253994 @default.
• W1976200636 cites W1997504014 @default.
• W1976200636 cites W1999243658 @default.
• W1976200636 cites W2000319642 @default.
• W1976200636 cites W2011980209 @default.
• W1976200636 cites W2015314629 @default.
• W1976200636 cites W2020913453 @default.
• W1976200636 cites W2024569103 @default.
• W1976200636 cites W2027249101 @default.
• W1976200636 cites W2028970731 @default.
• W1976200636 cites W2037632318 @default.
• W1976200636 cites W2045234988 @default.
• W1976200636 cites W2047758365 @default.
• W1976200636 cites W2051239163 @default.
• W1976200636 cites W2051467321 @default.
• W1976200636 cites W2051795211 @default.
• W1976200636 cites W2052550299 @default.
• W1976200636 cites W2053894359 @default.
• W1976200636 cites W2059196682 @default.
• W1976200636 cites W2065436349 @default.
• W1976200636 cites W2069556083 @default.
• W1976200636 cites W2072749722 @default.
• W1976200636 cites W2079634451 @default.
• W1976200636 cites W2084028904 @default.
• W1976200636 cites W2084674294 @default.
• W1976200636 cites W2088408801 @default.
• W1976200636 cites W2090784962 @default.
• W1976200636 cites W2091950241 @default.
• W1976200636 cites W2094584332 @default.
• W1976200636 cites W2096057003 @default.
• W1976200636 cites W2097785509 @default.
• W1976200636 cites W2098275650 @default.
• W1976200636 cites W2108713158 @default.
• W1976200636 cites W2111208057 @default.
• W1976200636 cites W2113433199 @default.
• W1976200636 cites W2117058881 @default.
• W1976200636 cites W2117965440 @default.
• W1976200636 cites W2120016245 @default.
• W1976200636 cites W2122040085 @default.
• W1976200636 cites W2128932593 @default.
• W1976200636 cites W2130355910 @default.
• W1976200636 cites W2130706354 @default.
• W1976200636 cites W2133812508 @default.
• W1976200636 cites W2135197754 @default.
• W1976200636 cites W2136841975 @default.
• W1976200636 cites W2137750805 @default.
• W1976200636 cites W2140946052 @default.
• W1976200636 cites W2143202717 @default.
• W1976200636 cites W2146140843 @default.
• W1976200636 cites W2152712415 @default.
• W1976200636 cites W2153456169 @default.
• W1976200636 cites W2159482845 @default.
• W1976200636 cites W2159725359 @default.
• W1976200636 cites W2165541514 @default.
• W1976200636 cites W2170192148 @default.
• W1976200636 cites W2171530407 @default.
• W1976200636 cites W4256409604 @default.
• W1976200636 doi "https://doi.org/10.1039/b717542f" @default.
• W1976200636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18563251" @default.
• W1976200636 hasPublicationYear "2008" @default.
• W1976200636 type Work @default.
• W1976200636 sameAs 1976200636 @default.
• W1976200636 citedByCount "50" @default.
• W1976200636 countsByYear W19762006362012 @default.
• W1976200636 countsByYear W19762006362013 @default.
• W1976200636 countsByYear W19762006362014 @default.
• W1976200636 countsByYear W19762006362015 @default.
• W1976200636 countsByYear W19762006362016 @default.
• W1976200636 countsByYear W19762006362017 @default.
• W1976200636 countsByYear W19762006362018 @default.
• W1976200636 countsByYear W19762006362019 @default.
• W1976200636 countsByYear W19762006362020 @default.
• W1976200636 crossrefType "journal-article" @default.
• W1976200636 hasAuthorship W1976200636A5011029168 @default.
• W1976200636 hasAuthorship W1976200636A5025268507 @default.
• W1976200636 hasAuthorship W1976200636A5041682013 @default.
• W1976200636 hasAuthorship W1976200636A5051341401 @default.
• W1976200636 hasAuthorship W1976200636A5055656807 @default.

• next