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- W1976208051 abstract "To probe the mechanism by which Ca(2+) activates muscle contraction through tropomyosin and troponin, we have produced mutant actins using Dictyostelium discoideum. We focused on the sequence 228-232 (QTAAS) that is located in subdomain 4 of actin, because the chimera actin in which this sequence was replaced by KAYKE showed not only poorer tropomyosin binding but also the unexpected higher Ca(2+) activation [Saeki, K., et al. (1996) Biochemistry 35, 14465-14472]. We found that this higher Ca(2+) activation is solely due to the A230Y mutagenesis. Because A230Y mutant actin showed normal tropomyosin binding, the higher Ca(2+) activation is not the consequence of poorer tropomyosin binding. The significance of these results is discussed in view of a three-state model [McKillop, D. F., Geeves, M. A. (1993) Biophys. J. 65, 693-701]." @default.
- W1976208051 created "2016-06-24" @default.
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- W1976208051 date "2000-01-21" @default.
- W1976208051 modified "2023-09-30" @default.
- W1976208051 title "A230Y Mutation of Actin on Subdomain 4 Is Sufficient for Higher Calcium Activation of Actin-Activated Myosin Adenosinetriphosphatase in the Presence of Tropomyosin−Troponin†" @default.
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- W1976208051 doi "https://doi.org/10.1021/bi991297k" @default.
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