FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976222009> ?p ?o ?g. }

• W1976222009 endingPage "954" @default.
• W1976222009 startingPage "949" @default.
• W1976222009 abstract "Purpose Locally advanced rectal cancer represents a major therapeutic challenge. Preoperative chemoradiation therapy is considered standard, but little is known about the dose-effect relationship. The present study represents a dose-escalation phase III trial comparing 2 doses of radiation. Methods and Materials The inclusion criteria were resectable T3 and T4 tumors with a circumferential margin of ≤5 mm on magnetic resonance imaging. The patients were randomized to receive 50.4 Gy in 28 fractions to the tumor and pelvic lymph nodes (arm A) or the same treatment supplemented with an endorectal boost given as high-dose-rate brachytherapy (10 Gy in 2 fractions; arm B). Concomitant chemotherapy, uftoral 300 mg/m2 and L-leucovorin 22.5 mg/d, was added to both arms on treatment days. The primary endpoint was complete pathologic remission. The secondary endpoints included tumor response and rate of complete resection (R0). Results The study included 248 patients. No significant difference was found in toxicity or surgical complications between the 2 groups. Based on intention to treat, no significant difference was found in the complete pathologic remission rate between the 2 arms (18% and 18%). The rate of R0 resection was different in T3 tumors (90% and 99%; P=.03). The same applied to the rate of major response (tumor regression grade, 1+2), 29% and 44%, respectively (P=.04). Conclusions This first randomized trial comparing 2 radiation doses indicated that the higher dose increased the rate of major response by 50% in T3 tumors. The endorectal boost is feasible, with no significant increase in toxicity or surgical complications. Locally advanced rectal cancer represents a major therapeutic challenge. Preoperative chemoradiation therapy is considered standard, but little is known about the dose-effect relationship. The present study represents a dose-escalation phase III trial comparing 2 doses of radiation. The inclusion criteria were resectable T3 and T4 tumors with a circumferential margin of ≤5 mm on magnetic resonance imaging. The patients were randomized to receive 50.4 Gy in 28 fractions to the tumor and pelvic lymph nodes (arm A) or the same treatment supplemented with an endorectal boost given as high-dose-rate brachytherapy (10 Gy in 2 fractions; arm B). Concomitant chemotherapy, uftoral 300 mg/m2 and L-leucovorin 22.5 mg/d, was added to both arms on treatment days. The primary endpoint was complete pathologic remission. The secondary endpoints included tumor response and rate of complete resection (R0). The study included 248 patients. No significant difference was found in toxicity or surgical complications between the 2 groups. Based on intention to treat, no significant difference was found in the complete pathologic remission rate between the 2 arms (18% and 18%). The rate of R0 resection was different in T3 tumors (90% and 99%; P=.03). The same applied to the rate of major response (tumor regression grade, 1+2), 29% and 44%, respectively (P=.04). This first randomized trial comparing 2 radiation doses indicated that the higher dose increased the rate of major response by 50% in T3 tumors. The endorectal boost is feasible, with no significant increase in toxicity or surgical complications." @default.
• W1976222009 created "2016-06-24" @default.
• W1976222009 creator A5010297386 @default.
• W1976222009 creator A5030376889 @default.
• W1976222009 creator A5046597293 @default.
• W1976222009 creator A5048866467 @default.
• W1976222009 creator A5086473862 @default.
• W1976222009 creator A5088764523 @default.
• W1976222009 date "2012-11-01" @default.
• W1976222009 modified "2023-09-30" @default.
• W1976222009 title "Dose-Effect Relationship in Chemoradiotherapy for Locally Advanced Rectal Cancer: A Randomized Trial Comparing Two Radiation Doses" @default.
• W1976222009 cites W1963639848 @default.
• W1976222009 cites W1974698218 @default.
• W1976222009 cites W1977468182 @default.
• W1976222009 cites W1996916701 @default.
• W1976222009 cites W1998342551 @default.
• W1976222009 cites W2000393470 @default.
• W1976222009 cites W2000807684 @default.
• W1976222009 cites W2027441417 @default.
• W1976222009 cites W2036595545 @default.
• W1976222009 cites W2036704220 @default.
• W1976222009 cites W2055348823 @default.
• W1976222009 cites W2087830202 @default.
• W1976222009 cites W2099027798 @default.
• W1976222009 cites W2108051921 @default.
• W1976222009 cites W2113353705 @default.
• W1976222009 cites W2124886112 @default.
• W1976222009 cites W2125452425 @default.
• W1976222009 cites W2159691094 @default.
• W1976222009 doi "https://doi.org/10.1016/j.ijrobp.2012.02.006" @default.
• W1976222009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22592048" @default.
• W1976222009 hasPublicationYear "2012" @default.
• W1976222009 type Work @default.
• W1976222009 sameAs 1976222009 @default.
• W1976222009 citedByCount "94" @default.
• W1976222009 countsByYear W19762220092012 @default.
• W1976222009 countsByYear W19762220092013 @default.
• W1976222009 countsByYear W19762220092014 @default.
• W1976222009 countsByYear W19762220092015 @default.
• W1976222009 countsByYear W19762220092016 @default.
• W1976222009 countsByYear W19762220092017 @default.
• W1976222009 countsByYear W19762220092018 @default.
• W1976222009 countsByYear W19762220092019 @default.
• W1976222009 countsByYear W19762220092020 @default.
• W1976222009 countsByYear W19762220092021 @default.
• W1976222009 countsByYear W19762220092022 @default.
• W1976222009 countsByYear W19762220092023 @default.
• W1976222009 crossrefType "journal-article" @default.
• W1976222009 hasAuthorship W1976222009A5010297386 @default.
• W1976222009 hasAuthorship W1976222009A5030376889 @default.
• W1976222009 hasAuthorship W1976222009A5046597293 @default.
• W1976222009 hasAuthorship W1976222009A5048866467 @default.
• W1976222009 hasAuthorship W1976222009A5086473862 @default.
• W1976222009 hasAuthorship W1976222009A5088764523 @default.
• W1976222009 hasConcept C121608353 @default.
• W1976222009 hasConcept C126322002 @default.
• W1976222009 hasConcept C126838900 @default.
• W1976222009 hasConcept C126894567 @default.
• W1976222009 hasConcept C141071460 @default.
• W1976222009 hasConcept C143409427 @default.
• W1976222009 hasConcept C168563851 @default.
• W1976222009 hasConcept C203092338 @default.
• W1976222009 hasConcept C2777416452 @default.
• W1976222009 hasConcept C2778424827 @default.
• W1976222009 hasConcept C2779384505 @default.
• W1976222009 hasConcept C2781074409 @default.
• W1976222009 hasConcept C2989005 @default.
• W1976222009 hasConcept C509974204 @default.
• W1976222009 hasConcept C526805850 @default.
• W1976222009 hasConcept C71924100 @default.
• W1976222009 hasConceptScore W1976222009C121608353 @default.
• W1976222009 hasConceptScore W1976222009C126322002 @default.
• W1976222009 hasConceptScore W1976222009C126838900 @default.
• W1976222009 hasConceptScore W1976222009C126894567 @default.
• W1976222009 hasConceptScore W1976222009C141071460 @default.
• W1976222009 hasConceptScore W1976222009C143409427 @default.
• W1976222009 hasConceptScore W1976222009C168563851 @default.
• W1976222009 hasConceptScore W1976222009C203092338 @default.
• W1976222009 hasConceptScore W1976222009C2777416452 @default.
• W1976222009 hasConceptScore W1976222009C2778424827 @default.
• W1976222009 hasConceptScore W1976222009C2779384505 @default.
• W1976222009 hasConceptScore W1976222009C2781074409 @default.
• W1976222009 hasConceptScore W1976222009C2989005 @default.
• W1976222009 hasConceptScore W1976222009C509974204 @default.
• W1976222009 hasConceptScore W1976222009C526805850 @default.
• W1976222009 hasConceptScore W1976222009C71924100 @default.
• W1976222009 hasIssue "4" @default.
• W1976222009 hasLocation W19762220091 @default.
• W1976222009 hasLocation W19762220092 @default.
• W1976222009 hasOpenAccess W1976222009 @default.
• W1976222009 hasPrimaryLocation W19762220091 @default.
• W1976222009 hasRelatedWork W2057978271 @default.
• W1976222009 hasRelatedWork W2150621467 @default.
• W1976222009 hasRelatedWork W2278841906 @default.
• W1976222009 hasRelatedWork W2373906005 @default.
• W1976222009 hasRelatedWork W2419663817 @default.
• W1976222009 hasRelatedWork W2438247724 @default.
• W1976222009 hasRelatedWork W2943654241 @default.

• next