Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976226543> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1976226543 endingPage "624" @default.
- W1976226543 startingPage "618" @default.
- W1976226543 abstract "Summary Behçet’s disease (BD) is a chronic inflammatory disorder in which thrombosis occurs in about 30% of patients. The prothrombotic mechanisms are unknown. Thrombophilic defects and hyperhomocysteinaemia may be involved in the pathogenesis of thrombotic events, although results have been controversial. Moreover, no information is available on this issue for eastern Spain.We studied the prevalence of inherited and acquired thrombophilic risk factors in 79 patients with BD (43 men, 36 women) who had (n = 23) or did not have (n = 56) thrombosis, and in 84 healthy control subjects (42 men, 42 women). Risk factors examined were antithrombin, protein C and protein S levels, factor V Leiden, the prothrombin G20210A mutation, the methylenetetrahydrofolate reductase C677T polymorphism, and acquired thrombophilic risk factors, including anticardiolipin antibodies, lupus anticoagulant, and serum homocysteine levels. There were no differences between patients and controls in any of the parameters studied.When we studied BD patients with and without thrombotic events, the only thrombophilic defect that differed was the prothrombin G20210A mutation: Three out of 23 patients with thrombosis were carriers, compared with none of 56 patients without thrombosis (p = 0.022).Two of the three carriers developed catastrophic or recurrent thrombotic episodes; one wasa homozygous carrier of the G20210A prothrombin mutation and the other was doubly heterozygous for the G20210A prothrombin mutation and factor V Leiden. A meta-analysis demonstrated an association of factor V Leiden and prothrombin mutation with thrombosis in BD. When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis." @default.
- W1976226543 created "2016-06-24" @default.
- W1976226543 creator A5021978850 @default.
- W1976226543 creator A5026232495 @default.
- W1976226543 creator A5029943902 @default.
- W1976226543 creator A5053484499 @default.
- W1976226543 creator A5057986151 @default.
- W1976226543 creator A5058115278 @default.
- W1976226543 creator A5068695724 @default.
- W1976226543 creator A5078413600 @default.
- W1976226543 creator A5079018683 @default.
- W1976226543 creator A5091085793 @default.
- W1976226543 date "2006-01-01" @default.
- W1976226543 modified "2023-10-16" @default.
- W1976226543 title "Thrombophilic risk factors and homocysteine levels in Behçet’s disease in eastern Spain and their association with thrombotic events" @default.
- W1976226543 doi "https://doi.org/10.1160/th05-10-0659" @default.
- W1976226543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16601831" @default.
- W1976226543 hasPublicationYear "2006" @default.
- W1976226543 type Work @default.
- W1976226543 sameAs 1976226543 @default.
- W1976226543 citedByCount "51" @default.
- W1976226543 countsByYear W19762265432012 @default.
- W1976226543 countsByYear W19762265432013 @default.
- W1976226543 countsByYear W19762265432014 @default.
- W1976226543 countsByYear W19762265432015 @default.
- W1976226543 countsByYear W19762265432016 @default.
- W1976226543 countsByYear W19762265432017 @default.
- W1976226543 countsByYear W19762265432022 @default.
- W1976226543 crossrefType "journal-article" @default.
- W1976226543 hasAuthorship W1976226543A5021978850 @default.
- W1976226543 hasAuthorship W1976226543A5026232495 @default.
- W1976226543 hasAuthorship W1976226543A5029943902 @default.
- W1976226543 hasAuthorship W1976226543A5053484499 @default.
- W1976226543 hasAuthorship W1976226543A5057986151 @default.
- W1976226543 hasAuthorship W1976226543A5058115278 @default.
- W1976226543 hasAuthorship W1976226543A5068695724 @default.
- W1976226543 hasAuthorship W1976226543A5078413600 @default.
- W1976226543 hasAuthorship W1976226543A5079018683 @default.
- W1976226543 hasAuthorship W1976226543A5091085793 @default.
- W1976226543 hasConcept C104317684 @default.
- W1976226543 hasConcept C126322002 @default.
- W1976226543 hasConcept C135763542 @default.
- W1976226543 hasConcept C203014093 @default.
- W1976226543 hasConcept C2776046644 @default.
- W1976226543 hasConcept C2776523773 @default.
- W1976226543 hasConcept C2777090595 @default.
- W1976226543 hasConcept C2777175894 @default.
- W1976226543 hasConcept C2777872019 @default.
- W1976226543 hasConcept C2780011451 @default.
- W1976226543 hasConcept C2780022809 @default.
- W1976226543 hasConcept C2780842393 @default.
- W1976226543 hasConcept C2780868729 @default.
- W1976226543 hasConcept C43563269 @default.
- W1976226543 hasConcept C50440223 @default.
- W1976226543 hasConcept C54355233 @default.
- W1976226543 hasConcept C71924100 @default.
- W1976226543 hasConcept C86803240 @default.
- W1976226543 hasConcept C90924648 @default.
- W1976226543 hasConceptScore W1976226543C104317684 @default.
- W1976226543 hasConceptScore W1976226543C126322002 @default.
- W1976226543 hasConceptScore W1976226543C135763542 @default.
- W1976226543 hasConceptScore W1976226543C203014093 @default.
- W1976226543 hasConceptScore W1976226543C2776046644 @default.
- W1976226543 hasConceptScore W1976226543C2776523773 @default.
- W1976226543 hasConceptScore W1976226543C2777090595 @default.
- W1976226543 hasConceptScore W1976226543C2777175894 @default.
- W1976226543 hasConceptScore W1976226543C2777872019 @default.
- W1976226543 hasConceptScore W1976226543C2780011451 @default.
- W1976226543 hasConceptScore W1976226543C2780022809 @default.
- W1976226543 hasConceptScore W1976226543C2780842393 @default.
- W1976226543 hasConceptScore W1976226543C2780868729 @default.
- W1976226543 hasConceptScore W1976226543C43563269 @default.
- W1976226543 hasConceptScore W1976226543C50440223 @default.
- W1976226543 hasConceptScore W1976226543C54355233 @default.
- W1976226543 hasConceptScore W1976226543C71924100 @default.
- W1976226543 hasConceptScore W1976226543C86803240 @default.
- W1976226543 hasConceptScore W1976226543C90924648 @default.
- W1976226543 hasFunder F4320310220 @default.
- W1976226543 hasIssue "04" @default.
- W1976226543 hasLocation W19762265431 @default.
- W1976226543 hasLocation W19762265432 @default.
- W1976226543 hasOpenAccess W1976226543 @default.
- W1976226543 hasPrimaryLocation W19762265431 @default.
- W1976226543 hasRelatedWork W1763958285 @default.
- W1976226543 hasRelatedWork W1792182519 @default.
- W1976226543 hasRelatedWork W1997594563 @default.
- W1976226543 hasRelatedWork W2016755108 @default.
- W1976226543 hasRelatedWork W2057984106 @default.
- W1976226543 hasRelatedWork W2069657927 @default.
- W1976226543 hasRelatedWork W2085860667 @default.
- W1976226543 hasRelatedWork W2086347517 @default.
- W1976226543 hasRelatedWork W2088607865 @default.
- W1976226543 hasRelatedWork W2261277369 @default.
- W1976226543 hasVolume "95" @default.
- W1976226543 isParatext "false" @default.
- W1976226543 isRetracted "false" @default.
- W1976226543 magId "1976226543" @default.
- W1976226543 workType "article" @default.