Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976237335> ?p ?o ?g. }
- W1976237335 endingPage "11" @default.
- W1976237335 startingPage "1" @default.
- W1976237335 abstract "Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. TRAIL activates NF-kappaB in tubular cells and promotes apoptosis in tubular cells and podocytes, especially in a high-glucose environment. By contrast, osteoprotegerin plays a protective role against TRAIL-induced apoptosis. Another family member, TNF-like weak inducer of apoptosis (TWEAK induces inflammation and tubular cell death or proliferation, depending on the microenvironment. While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses. TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. In vivo TWEAK promotes postnephrectomy compensatory renal cell proliferation in a noninflammatory milieu. However, in the inflammatory milieu of acute kidney injury, TWEAK promotes tubular cell death and inflammation. Therapeutic targeting of TNF superfamily cytokines, including multipronged approaches targeting several cytokines should be further explored." @default.
- W1976237335 created "2016-06-24" @default.
- W1976237335 creator A5003545733 @default.
- W1976237335 creator A5004285499 @default.
- W1976237335 creator A5005804630 @default.
- W1976237335 creator A5032793638 @default.
- W1976237335 creator A5033799298 @default.
- W1976237335 creator A5044674650 @default.
- W1976237335 creator A5045038056 @default.
- W1976237335 creator A5054627794 @default.
- W1976237335 creator A5063245254 @default.
- W1976237335 creator A5064747640 @default.
- W1976237335 creator A5087371457 @default.
- W1976237335 creator A5089462896 @default.
- W1976237335 date "2010-01-01" @default.
- W1976237335 modified "2023-10-18" @default.
- W1976237335 title "TNF Superfamily: A Growing Saga of Kidney Injury Modulators" @default.
- W1976237335 cites W105127712 @default.
- W1976237335 cites W1484817497 @default.
- W1976237335 cites W1503094954 @default.
- W1976237335 cites W1518420099 @default.
- W1976237335 cites W1527985047 @default.
- W1976237335 cites W1528876949 @default.
- W1976237335 cites W1560704839 @default.
- W1976237335 cites W1562444807 @default.
- W1976237335 cites W1568796088 @default.
- W1976237335 cites W1674551699 @default.
- W1976237335 cites W1893773267 @default.
- W1976237335 cites W1967992807 @default.
- W1976237335 cites W1969187681 @default.
- W1976237335 cites W1970483076 @default.
- W1976237335 cites W1971604648 @default.
- W1976237335 cites W1973158357 @default.
- W1976237335 cites W1975024594 @default.
- W1976237335 cites W1975291295 @default.
- W1976237335 cites W1975939608 @default.
- W1976237335 cites W1979396507 @default.
- W1976237335 cites W1979445622 @default.
- W1976237335 cites W1982082886 @default.
- W1976237335 cites W1989783048 @default.
- W1976237335 cites W1993889413 @default.
- W1976237335 cites W1994696929 @default.
- W1976237335 cites W1995979596 @default.
- W1976237335 cites W1996263867 @default.
- W1976237335 cites W2000647744 @default.
- W1976237335 cites W2000934675 @default.
- W1976237335 cites W2016345107 @default.
- W1976237335 cites W2016928970 @default.
- W1976237335 cites W2017578232 @default.
- W1976237335 cites W2019746317 @default.
- W1976237335 cites W2021323060 @default.
- W1976237335 cites W2021413266 @default.
- W1976237335 cites W2025047441 @default.
- W1976237335 cites W2037308808 @default.
- W1976237335 cites W2037976034 @default.
- W1976237335 cites W2038034205 @default.
- W1976237335 cites W2038656874 @default.
- W1976237335 cites W2039714220 @default.
- W1976237335 cites W2041466047 @default.
- W1976237335 cites W2041531589 @default.
- W1976237335 cites W2045754587 @default.
- W1976237335 cites W2046309102 @default.
- W1976237335 cites W2046382304 @default.
- W1976237335 cites W2048615690 @default.
- W1976237335 cites W2049312704 @default.
- W1976237335 cites W2049365136 @default.
- W1976237335 cites W2049761545 @default.
- W1976237335 cites W2053792223 @default.
- W1976237335 cites W2056217426 @default.
- W1976237335 cites W2056657456 @default.
- W1976237335 cites W2058445558 @default.
- W1976237335 cites W2059351462 @default.
- W1976237335 cites W2060960232 @default.
- W1976237335 cites W2061430098 @default.
- W1976237335 cites W2062072353 @default.
- W1976237335 cites W2068398404 @default.
- W1976237335 cites W2069681479 @default.
- W1976237335 cites W2070854099 @default.
- W1976237335 cites W2074592829 @default.
- W1976237335 cites W2074631672 @default.
- W1976237335 cites W2075273683 @default.
- W1976237335 cites W2075476584 @default.
- W1976237335 cites W2083601744 @default.
- W1976237335 cites W2085701360 @default.
- W1976237335 cites W2090814843 @default.
- W1976237335 cites W2094313417 @default.
- W1976237335 cites W2094816353 @default.
- W1976237335 cites W2096922032 @default.
- W1976237335 cites W2099096560 @default.
- W1976237335 cites W2099516468 @default.
- W1976237335 cites W2100203253 @default.
- W1976237335 cites W2100682112 @default.
- W1976237335 cites W2102563764 @default.
- W1976237335 cites W2103258308 @default.
- W1976237335 cites W2103691848 @default.
- W1976237335 cites W2105109792 @default.
- W1976237335 cites W2112819410 @default.
- W1976237335 cites W2113621700 @default.