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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976237649> ?p ?o ?g. }

• W1976237649 endingPage "675" @default.
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• W1976237649 abstract "Objective: To describe the use of temozolomide (TMZ) in Canadian children treated for brain tumours and to evaluate survival and predictors of survival for children treated with this agent. Methods: A survey was conducted within the Canadian Paediatric Brain Tumour Consortium (CPBTC), a group of tertiary care centres in pediatric neurooncology (n = 16) in Canada that are involved in the treatment of children with central nervous system tumours. Results: In 10 of the 16 participating pediatric oncology centres of the CPBTC, 137 children with brain tumours were treated with TMZ between January 2000 and March 2006. Although 33% of the children were enrolled into a clinical trial, 67% were treated outside open studies. Most patients (72%) received TMZ treatment on recurrence of their brain tumour (first or subsequent). The most commonly administered regimen was single-agent TMZ 150–200 mg/ m2 administered on 5 consecutive days every 28 days. The median duration of TMZ treatment was 141 days (range: 4–1102 days). Response data were provided for 127 of the 137 patients, of whom 6 showed a complete response. Sixteen patients experienced a minor or partial response, 53 had stable disease, and 52 had progressive disease. Of 32 patients alive at last follow-up, 19 had a diagnosis of low-grade glioma." @default.
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• W1976237649 date "2011-02-01" @default.
• W1976237649 modified "2023-10-13" @default.
• W1976237649 title "The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium" @default.
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• W1976237649 doi "https://doi.org/10.3747/co.v18i1.675" @default.
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