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- W1976242511 endingPage "897" @default.
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- W1976242511 abstract "Chromatin remodeling by Polycomb group (PcG) and trithorax group (trxG) proteins regulates gene expression in all metazoans. Two major complexes, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), are thought to mediate PcG-dependent repression in flies and mammals. In Drosophila, PcG/trxG protein complexes are recruited by PcG/trxG response elements (PREs). However, it has been unclear how PcG/trxG are recruited in vertebrates. Here we have identified a vertebrate PRE, PRE-kr, that regulates expression of the mouse MafB/Kreisler gene. PRE-kr recruits PcG proteins in flies and mouse F9 cells and represses gene expression in a PcG/trxG-dependent manner. PRC1 and 2 bind to a minimal PRE-kr region, which can recruit stable PRC1 binding but only weak PRC2 binding when introduced ectopically, suggesting that PRC1 and 2 have different binding requirements. Thus, we provide evidence that similar to invertebrates, PREs act as entry sites for PcG/trxG chromatin remodeling in vertebrates." @default.
- W1976242511 created "2016-06-24" @default.
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- W1976242511 date "2009-09-01" @default.
- W1976242511 modified "2023-10-16" @default.
- W1976242511 title "A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain" @default.
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- W1976242511 doi "https://doi.org/10.1016/j.cell.2009.08.020" @default.
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