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- W1976249916 endingPage "114" @default.
- W1976249916 startingPage "94" @default.
- W1976249916 abstract "Cultured cells are widely used in the evaluation of new drugs and drug delivery systems. Cells can be grown at different levels of complexity ranging from simple reductionist models to complex organotypic models. The models are based on primary, secondary or stem cell derived cell cultures. Generation of tissue mimics with cultured cells is a difficult task, because the tissues have well-defined morphology, complex protein expression patterns and multiple inter-linked functions. Development of organotypic cell culture models requires proper biomaterial matrix and cell culture protocols that are able to guide the cells to the correct phenotype. This review illustrates the critical features of the cell culture models and, then, selected models are discussed in more detail (epidermal, corneal epithelial, retinal pigment epithelium, and hepatocyte models). The cell models are critically evaluated paying attention to the level of characterization and reliability of in vivo translation. Properties of the cell models must be characterized in detail using multiple biological assays and broad sets of model drugs. Robust in vivo predictions can be achieved with well-characterized cell models that are used in combination with computational methods that will bridge the gap between in vitro cell experiments and physiological situation in vivo in the body." @default.
- W1976249916 created "2016-06-24" @default.
- W1976249916 creator A5030491662 @default.
- W1976249916 creator A5032763232 @default.
- W1976249916 creator A5038861002 @default.
- W1976249916 creator A5041272614 @default.
- W1976249916 creator A5051301935 @default.
- W1976249916 creator A5053032683 @default.
- W1976249916 creator A5059004630 @default.
- W1976249916 creator A5065810893 @default.
- W1976249916 creator A5088548378 @default.
- W1976249916 date "2014-09-01" @default.
- W1976249916 modified "2023-10-01" @default.
- W1976249916 title "A critical assessment of in vitro tissue models for ADME and drug delivery" @default.
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