FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976265855> ?p ?o ?g. }

• W1976265855 endingPage "408" @default.
• W1976265855 startingPage "403" @default.
• W1976265855 abstract "Summary This study introduces a new laboratory model of whole blood platelet aggregation stimulated by endogenously generated thrombin, and explores this aspect in haemophilia A in which impaired thrombin generation is a major hallmark. The method was established to measure platelet aggregation initiated by tissue factor evaluated by means of impedance aggregometry. Citrated whole blood from healthy volunteers and haemophilia A patients with the addition of inhibitors of the contact pathway and fibrin polymerization was evaluated. In healthy persons, a second wave of platelet aggregation was found to coincide with the thrombin burst and to be abolished by thrombin inhibitors. In this system, platelet aggregation in severe haemophilia A ( n = 10) was found to be significantly decreased as compared with healthy individuals (912 ± 294 vs. 1917 ± 793 AU × min, P = 0.003), most probably due to the weak level of thrombin generation. For the first time, analysis of platelet aggregation as induced by endogenously generated thrombin was demonstrated. The new method makes it possible to explore the influence of the coagulation system on platelet function. In contrast to the general understanding, the data suggest that the impaired thrombin generation in haemophilia may affect platelet activation. Future studies will address whether our results may contribute to understanding differences in bleeding phenotypes and response to haemostatic substitution observed among patients." @default.
• W1976265855 created "2016-06-24" @default.
• W1976265855 creator A5008027773 @default.
• W1976265855 creator A5027297357 @default.
• W1976265855 creator A5032700341 @default.
• W1976265855 creator A5042563060 @default.
• W1976265855 creator A5066208623 @default.
• W1976265855 creator A5075239871 @default.
• W1976265855 date "2013-02-06" @default.
• W1976265855 modified "2023-10-17" @default.
• W1976265855 title "Platelet activation and aggregation: the importance of thrombin activity-A laboratory model" @default.
• W1976265855 cites W110545565 @default.
• W1976265855 cites W187459506 @default.
• W1976265855 cites W1969704362 @default.
• W1976265855 cites W1970976986 @default.
• W1976265855 cites W1991130709 @default.
• W1976265855 cites W1994393898 @default.
• W1976265855 cites W2006068735 @default.
• W1976265855 cites W2006432872 @default.
• W1976265855 cites W2018784308 @default.
• W1976265855 cites W2030183201 @default.
• W1976265855 cites W2030561522 @default.
• W1976265855 cites W2036348577 @default.
• W1976265855 cites W2037652834 @default.
• W1976265855 cites W2041726150 @default.
• W1976265855 cites W2054656237 @default.
• W1976265855 cites W2055477312 @default.
• W1976265855 cites W2066304010 @default.
• W1976265855 cites W2106813936 @default.
• W1976265855 cites W2119768870 @default.
• W1976265855 cites W2128139337 @default.
• W1976265855 cites W2129420064 @default.
• W1976265855 cites W2132117562 @default.
• W1976265855 cites W2142247970 @default.
• W1976265855 cites W2150428823 @default.
• W1976265855 cites W2153249364 @default.
• W1976265855 doi "https://doi.org/10.1111/hae.12099" @default.
• W1976265855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23387870" @default.
• W1976265855 hasPublicationYear "2013" @default.
• W1976265855 type Work @default.
• W1976265855 sameAs 1976265855 @default.
• W1976265855 citedByCount "9" @default.
• W1976265855 countsByYear W19762658552014 @default.
• W1976265855 countsByYear W19762658552015 @default.
• W1976265855 countsByYear W19762658552017 @default.
• W1976265855 countsByYear W19762658552018 @default.
• W1976265855 countsByYear W19762658552020 @default.
• W1976265855 countsByYear W19762658552021 @default.
• W1976265855 countsByYear W19762658552022 @default.
• W1976265855 crossrefType "journal-article" @default.
• W1976265855 hasAuthorship W1976265855A5008027773 @default.
• W1976265855 hasAuthorship W1976265855A5027297357 @default.
• W1976265855 hasAuthorship W1976265855A5032700341 @default.
• W1976265855 hasAuthorship W1976265855A5042563060 @default.
• W1976265855 hasAuthorship W1976265855A5066208623 @default.
• W1976265855 hasAuthorship W1976265855A5075239871 @default.
• W1976265855 hasConcept C126322002 @default.
• W1976265855 hasConcept C141071460 @default.
• W1976265855 hasConcept C203014093 @default.
• W1976265855 hasConcept C2777232031 @default.
• W1976265855 hasConcept C2777292125 @default.
• W1976265855 hasConcept C2778382381 @default.
• W1976265855 hasConcept C2778385053 @default.
• W1976265855 hasConcept C3018697912 @default.
• W1976265855 hasConcept C3018972837 @default.
• W1976265855 hasConcept C54173615 @default.
• W1976265855 hasConcept C71924100 @default.
• W1976265855 hasConcept C89560881 @default.
• W1976265855 hasConcept C98274493 @default.
• W1976265855 hasConceptScore W1976265855C126322002 @default.
• W1976265855 hasConceptScore W1976265855C141071460 @default.
• W1976265855 hasConceptScore W1976265855C203014093 @default.
• W1976265855 hasConceptScore W1976265855C2777232031 @default.
• W1976265855 hasConceptScore W1976265855C2777292125 @default.
• W1976265855 hasConceptScore W1976265855C2778382381 @default.
• W1976265855 hasConceptScore W1976265855C2778385053 @default.
• W1976265855 hasConceptScore W1976265855C3018697912 @default.
• W1976265855 hasConceptScore W1976265855C3018972837 @default.
• W1976265855 hasConceptScore W1976265855C54173615 @default.
• W1976265855 hasConceptScore W1976265855C71924100 @default.
• W1976265855 hasConceptScore W1976265855C89560881 @default.
• W1976265855 hasConceptScore W1976265855C98274493 @default.
• W1976265855 hasIssue "3" @default.
• W1976265855 hasLocation W19762658551 @default.
• W1976265855 hasLocation W19762658552 @default.
• W1976265855 hasOpenAccess W1976265855 @default.
• W1976265855 hasPrimaryLocation W19762658551 @default.
• W1976265855 hasRelatedWork W1995822104 @default.
• W1976265855 hasRelatedWork W2005719195 @default.
• W1976265855 hasRelatedWork W2058961497 @default.
• W1976265855 hasRelatedWork W2067082011 @default.
• W1976265855 hasRelatedWork W2086676349 @default.
• W1976265855 hasRelatedWork W2101928171 @default.
• W1976265855 hasRelatedWork W2166990743 @default.
• W1976265855 hasRelatedWork W3113163854 @default.
• W1976265855 hasRelatedWork W3155450815 @default.
• W1976265855 hasRelatedWork W4233505807 @default.
• W1976265855 hasVolume "19" @default.

• next