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• W1976272011 abstract "The hexane, dichloromethane, ethyl acetate and aqueous fractions of an ethanolic extract of Centratherum punctatum leaves were screened for antiplasmodial, HIV-1 reverse transcriptase inhibitory and cytotoxicity properties. The crude extract exhibited both antiplasmodial (IC50 = 3.2 μg/ml) and HIV-1 reverse transcriptase inhibitory (IC50 = 72.8 μg/ml) activities. A remarkable improvement in both antiplasmodial (IC50 = 0.419 μg/ml) and HIV-1 reverse transcriptase inhibitory (IC50 = 52.4 μg/ml) activities was observed with dichloromethane fraction. The study revealed the antiplasmodial and HIV-1 RT inhibitory effects of C. punctatum and its fractions, especially the dichloromethane fraction. However, its safety index values [antiplasmodial (0.2), HIV-1 reverse transcriptase inhibition (0.0017)] indicate that the fraction is cytotoxic." @default.
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• W1976272011 date "2014-01-01" @default.
• W1976272011 modified "2023-10-11" @default.
• W1976272011 title "Antiplasmodial, HIV-1 reverse transcriptase inhibitory and cytotoxicity properties of Centratherum punctatum Cass. and its fractions" @default.
• W1976272011 cites W1969503178 @default.
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• W1976272011 doi "https://doi.org/10.1016/j.sajb.2013.10.001" @default.
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