FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976274800> ?p ?o ?g. }

• W1976274800 endingPage "172" @default.
• W1976274800 startingPage "159" @default.
• W1976274800 abstract "Two analogs of a tachykinin family peptides - scyliorhinin II (ScyII): [Aib(16)]ScyII and [Sar(16)]ScyII were synthesized by the solid-phase method using Fmoc chemistry. Conformational studies in water and DMSO-d(6) on these peptides were performed using a combination of two-dimensional NMR and theoretical conformational analysis. The solution structure of the peptides studied is interpreted as an equilibrium of several conformers with different statistical weights. The structure of [Sar(16)]ScyII in water appeared to be more flexible, especially in the C-terminal fragment. A better defined structure for this analog was obtained in DMSO-d(6), in which the analysis resulted in a family of conformers with similar shapes. Some of these conformers were characterized by the presence of a 3(10)-helix in the N-terminal fragment and middle part of the molecule. The introduction of the Aib residue in position 16 significantly rigidifies the structure. For [Aib(16)]ScyII in both solvent systems very similar populations of conformations were obtained which are characterized by the presence of a 3(10)-helix in the 13-18 fragment. A common structural motif was found in conformationally constrained Cys(7)-Cys(13) fragment, which resembles the Greek letter 'omega'. The differences in the solution structure of the C-terminal fragment of the peptides studied are responsible for their specificity. [Aib(16)]ScyII showed 25% the agonistic activity of selective NK-3 agonist - senktide, but it also showed antagonist effect vs. this peptide, whereas [Sar(16)]ScyII appeared to be a full agonist of NK-3 tachykinin receptor." @default.
• W1976274800 created "2016-06-24" @default.
• W1976274800 creator A5007685909 @default.
• W1976274800 creator A5009768876 @default.
• W1976274800 creator A5023274863 @default.
• W1976274800 creator A5028826845 @default.
• W1976274800 creator A5040966351 @default.
• W1976274800 creator A5050197652 @default.
• W1976274800 creator A5052827727 @default.
• W1976274800 creator A5068648502 @default.
• W1976274800 date "2001-08-01" @default.
• W1976274800 modified "2023-10-07" @default.
• W1976274800 title "Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16" @default.
• W1976274800 cites W1994255749 @default.
• W1976274800 cites W1994820130 @default.
• W1976274800 cites W1996108175 @default.
• W1976274800 cites W1996911308 @default.
• W1976274800 cites W2003802570 @default.
• W1976274800 cites W2018339076 @default.
• W1976274800 cites W2022507044 @default.
• W1976274800 cites W2027589805 @default.
• W1976274800 cites W2037455416 @default.
• W1976274800 cites W2062081085 @default.
• W1976274800 cites W2074770586 @default.
• W1976274800 cites W2114722917 @default.
• W1976274800 cites W2125128518 @default.
• W1976274800 cites W2129509556 @default.
• W1976274800 cites W2165996087 @default.
• W1976274800 cites W2171607531 @default.
• W1976274800 cites W309434687 @default.
• W1976274800 doi "https://doi.org/10.1034/j.1399-3011.2001.00886.x" @default.
• W1976274800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532075" @default.
• W1976274800 hasPublicationYear "2001" @default.
• W1976274800 type Work @default.
• W1976274800 sameAs 1976274800 @default.
• W1976274800 citedByCount "1" @default.
• W1976274800 crossrefType "journal-article" @default.
• W1976274800 hasAuthorship W1976274800A5007685909 @default.
• W1976274800 hasAuthorship W1976274800A5009768876 @default.
• W1976274800 hasAuthorship W1976274800A5023274863 @default.
• W1976274800 hasAuthorship W1976274800A5028826845 @default.
• W1976274800 hasAuthorship W1976274800A5040966351 @default.
• W1976274800 hasAuthorship W1976274800A5050197652 @default.
• W1976274800 hasAuthorship W1976274800A5052827727 @default.
• W1976274800 hasAuthorship W1976274800A5068648502 @default.
• W1976274800 hasConcept C118303440 @default.
• W1976274800 hasConcept C170493617 @default.
• W1976274800 hasConcept C178790620 @default.
• W1976274800 hasConcept C185592680 @default.
• W1976274800 hasConcept C18705241 @default.
• W1976274800 hasConcept C18903297 @default.
• W1976274800 hasConcept C2776533618 @default.
• W1976274800 hasConcept C2778530040 @default.
• W1976274800 hasConcept C2778938600 @default.
• W1976274800 hasConcept C2779281246 @default.
• W1976274800 hasConcept C2779965526 @default.
• W1976274800 hasConcept C2781338088 @default.
• W1976274800 hasConcept C32909587 @default.
• W1976274800 hasConcept C55493867 @default.
• W1976274800 hasConcept C55938493 @default.
• W1976274800 hasConcept C71240020 @default.
• W1976274800 hasConcept C86803240 @default.
• W1976274800 hasConceptScore W1976274800C118303440 @default.
• W1976274800 hasConceptScore W1976274800C170493617 @default.
• W1976274800 hasConceptScore W1976274800C178790620 @default.
• W1976274800 hasConceptScore W1976274800C185592680 @default.
• W1976274800 hasConceptScore W1976274800C18705241 @default.
• W1976274800 hasConceptScore W1976274800C18903297 @default.
• W1976274800 hasConceptScore W1976274800C2776533618 @default.
• W1976274800 hasConceptScore W1976274800C2778530040 @default.
• W1976274800 hasConceptScore W1976274800C2778938600 @default.
• W1976274800 hasConceptScore W1976274800C2779281246 @default.
• W1976274800 hasConceptScore W1976274800C2779965526 @default.
• W1976274800 hasConceptScore W1976274800C2781338088 @default.
• W1976274800 hasConceptScore W1976274800C32909587 @default.
• W1976274800 hasConceptScore W1976274800C55493867 @default.
• W1976274800 hasConceptScore W1976274800C55938493 @default.
• W1976274800 hasConceptScore W1976274800C71240020 @default.
• W1976274800 hasConceptScore W1976274800C86803240 @default.
• W1976274800 hasIssue "2" @default.
• W1976274800 hasLocation W19762748001 @default.
• W1976274800 hasLocation W19762748002 @default.
• W1976274800 hasOpenAccess W1976274800 @default.
• W1976274800 hasPrimaryLocation W19762748001 @default.
• W1976274800 hasRelatedWork W1967866503 @default.
• W1976274800 hasRelatedWork W1982180136 @default.
• W1976274800 hasRelatedWork W1986155861 @default.
• W1976274800 hasRelatedWork W1992675862 @default.
• W1976274800 hasRelatedWork W1999910034 @default.
• W1976274800 hasRelatedWork W2058584007 @default.
• W1976274800 hasRelatedWork W2076164295 @default.
• W1976274800 hasRelatedWork W2086819077 @default.
• W1976274800 hasRelatedWork W2089740733 @default.
• W1976274800 hasRelatedWork W3201429207 @default.
• W1976274800 hasVolume "58" @default.
• W1976274800 isParatext "false" @default.
• W1976274800 isRetracted "false" @default.
• W1976274800 magId "1976274800" @default.

• next