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• W1976282796 abstract "To analyze the length and area of corneal surface occupied by vessels, and their location in an experimental model of alkali burn-induced corneal neovascularization. An injury to the central cornea of the right eye in 91 Sprague-Dawley rats was induced using a silver nitrate pencil. The rats were divided into seven groups that were sacrificed 2, 4, 6, 8, 10, 12 and 14 days post-injury, and then perfused with a mixture of Chinese ink in PBS (phosphate buffer saline). Corneas were flat-mounted processed and divided into four quadrants. Corneal neovascular growth parameters (length and area) and the location of these vessels were performed blind. The results were statistically analyzed. Neovascular growth was observed from day 2, reaching its maximum peak in length and area on the 12th day post-injury. A slight reduction in corneal neovascularization was observed after this day. The vessels were initially located in the middle third of the stroma and tended to be observed in the anterior third during the course of the experiment. Neovascularisation was observed on day 2 post-injury in all sectors of corneal surface. Neovascular growth was uniform during the experiment. Neovessels were located in the middle and anterior third of the cornea. Analizar la longitud y área corneal ocupada por neovasos, así como la localización de estos, en un modelo experimental de neovascularización corneal por quemadura con álcali. Se utilizaron 91 ratas Sprague-Dawley en las que se realizó una quemadura en el centro de la córnea del ojo derecho utilizando un lápiz de nitrato de plata. Los animales fueron divididos en 7 grupos que fueron sacrificados a los 2, 4, 6, 8, 10, 12 y 14 días posquemadura, siendo perfundidos mediante una mezcla de tinta china y PBS (tampón fosfato salino). Las córneas fueron procesadas «a plano» y divididas en 4 cuadrantes. Se analizaron diferentes parámetros del crecimiento neovascular corneal (longitud y área), así como la localización de dichos neovasos de forma enmascarada. Los resultados fueron analizados estadísticamente. A partir del 2.° día se observa un crecimiento neovascular que alcanza su pico máximo a los 12 días posquemadura, tanto en longitud como en área. A partir de esta fecha se produce un débil retroceso del crecimiento neovascular. Los neovasos se localizan inicialmente en el tercio medio del estroma, tendiendo a situarse, a medida que transcurre el experimento, en el tercio anterior. La neovascularización se observó al 2.° día posquemadura en todos los sectores de la superficie corneal. El crecimiento neovascular fue uniforme durante todo el experimento. Los neovasos se localizaron en el tercio medio y anterior de la córnea." @default.
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• W1976282796 date "2014-08-01" @default.
• W1976282796 modified "2023-10-02" @default.
• W1976282796 title "Neovascular growth in an experimental alkali corneal burn model" @default.
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• W1976282796 doi "https://doi.org/10.1016/j.oftale.2014.08.012" @default.
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