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• W1976289277 abstract "1.1. One hundred ninety-six patients were treated with various types of fibrinolytic enzyme preparations. 2.2. Of 538 intravenous and/or intra-arterial infusions, hemorrhage occurred in twelve cases, and pulmonary embolism in two. 3.3. Pyrogenic side effects were seen commonly with earlier preparations but only four times in 385 treatments with newer, more purified preparations. 4.4. With four- to eight-hour infusions, decrease of factors of the blood clotting system was never of sufficient magnitude to be of clinical significance. Rapid intravenous injection resulted in more pronounced changes. Factors most often affected were prothrombin, factor V, factor VII and fibrinogen. 5.5. Retreatment with streptokinase or streptokinase-activated plasmin three weeks after an initial course of therapy resulted in anaphylactoid reactions in two of three cases. Retreatment with urokinase-activated plasmin caused no side effects and did not result in decreased therapeutic activity in twelve cases. 6.6. In cases of thrombophlebitis or thrombosis of the large veins (chiefly complications of neoplastic diseases in elderly patients) of less than five days' standing when treatment was initiated, of sixty-two patients treated with streptokinase, urokinase- or chloroform-activated plasmin, streptokinase or urokinase, alone or in combination with anticoagulants, twenty-eight (45 per cent) returned to normal and twenty (32 per cent) improved in less than five days, six (10 per cent) did not improve and one died of pulmonary embolism. All preparations used appeared to be therapeutically active. The objectives and methods of this study precluded the use of a matched control group of patients on a randomized double-blind basis. Nevertheless, therapeutic results in the groups of patients treated with fibrinolysin were superior to those in the untreated group or groups treated with anticoagulants." @default.
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• W1976289277 date "1960-08-01" @default.
• W1976289277 modified "2023-10-18" @default.
• W1976289277 title "Clinical pharmacology of various types of fibrinolytic enzyme preparations" @default.
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• W1976289277 doi "https://doi.org/10.1016/0002-9149(60)90340-4" @default.
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