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• W1976291255 endingPage "190" @default.
• W1976291255 startingPage "179" @default.
• W1976291255 abstract "3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured in the corpus striatum, nucleaus accumbens and tuberculum olfactorium of the rab brain. 4 antidepressants, 4 anesthetics, diprophylacetate, ethosuximide and metoclopramide induced a rise of DOPAC and HVA levels in the 3 brain regions. No change was observed after carbamazepine, diazepam or propranolol treatment. Combined treatment with a maximally effective dose of haloperidol and morphine, oxotremorine or probenecid produced and additional rise of imally effective dose of haloperidol and morphine, oxotremorine or probenecid produced and additional rise of DOPAC and HVA levels, while no additional rise was seen with chloral hydrate, chlorimipramine, ether, halothane, metoclopramide or sulpiride. The potency of drugs to increase DA metabolism in corpus striatum relative to mesolimbic structures was estimated. Atypical neuroleptics such as sulpiride could be differentiated in this respect from classical neuroleptics such as chlorpromazine, fluphenazine and thioridazine, by their ability to produce a relative large increase of metabolite levels in the mesolimbic regions. The heterogeneous group of 14 non-neuroleptics however produced regional changes which were very similar to those of the atypical neuroleptics. DA metabolism in mesolimbic regions, in contrast to striatal tissue, seems to respond more to atypical neuroleptics and non-neuroleptics than to typical neuroleptics." @default.
• W1976291255 created "2016-06-24" @default.
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• W1976291255 date "1977-03-01" @default.
• W1976291255 modified "2023-09-27" @default.
• W1976291255 title "On the significance of regional dopamine metabolism in the rat brain for the classification of centrally acting drugs" @default.
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• W1976291255 doi "https://doi.org/10.1016/0014-2999(77)90358-2" @default.
• W1976291255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/844497" @default.
• W1976291255 hasPublicationYear "1977" @default.
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