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- W1976291299 abstract "Graves' thyroid tissue has been shown to express elevated levels of human sodium/iodide symporter (hNIS) mRNA and protein. In the present work, we demonstrate for the first time that hNIS gene expression in Graves' disease (GD) is up-regulated by Graves' IgG. Here, in transient transfection experiments using FRTL-5 cells, hNIS promoter and enhancer/luciferase construct showed an up to six-fold increase in transcriptional activity after incubation with purified Graves' IgG. Mutation of a CRE site in hNIS enhancer inhibited Graves' IgG response. In addition, mutation of a novel putative regulatory region in hNIS promoter reduced the stimulation three-fold. This discovered putative regulatory sequence might play a role in hNIS up-regulation by Graves' IgG and TSH. The data presented here complement our current knowledge of the pathogenesis of GD and will contribute to a better understanding of mechanisms regulating the thyroid iodide concentrating activity." @default.
- W1976291299 created "2016-06-24" @default.
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- W1976291299 date "2003-12-01" @default.
- W1976291299 modified "2023-10-18" @default.
- W1976291299 title "Graves’ IgG activate upstream enhancer of the sodium/iodide symporter" @default.
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- W1976291299 doi "https://doi.org/10.1016/j.mce.2003.10.039" @default.
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