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• W1976298317 endingPage "1546" @default.
• W1976298317 startingPage "1542" @default.
• W1976298317 abstract "BackgroundIn the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates.ObjectivesWe exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1–4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning the threshold for cholinesterase inhibition: 0.5, 1, or 2 mg/kg for diazinon, and 0.02, 0.05, and 0.1 mg/kg for parathion.ResultsDiazinon evoked up-regulation of 5HT1A and 5HT2 receptor expression even at doses devoid of effects on cholinesterase activity, a pattern similar to that seen earlier for another organophosphate, chlorpyrifos. In contrast, parathion decreased 5HT1A receptors, again at doses below those required for effects on cholinesterase. The two agents also differed in their effects on the 5HT transporter. Diazinon evoked a decrease in the brainstem and an increase in the forebrain, again similar to that seen for chlorpyrifos; this pattern is typical of damage of nerve terminals and reactive sprouting. Parathion had smaller, nonsignificant effects.ConclusionsOur results buttress the idea that, in the developing brain, the various organophosphates target specific neurotransmitter systems differently from each other and without the requirement for cholinesterase inhibition, their supposed common mechanism of action." @default.
• W1976298317 created "2016-06-24" @default.
• W1976298317 creator A5000464378 @default.
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• W1976298317 date "2006-10-01" @default.
• W1976298317 modified "2023-10-16" @default.
• W1976298317 title "Organophosphate Insecticides Target the Serotonergic System in Developing Rat Brain Regions: Disparate Effects of Diazinon and Parathion at Doses Spanning the Threshold for Cholinesterase Inhibition" @default.
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• W1976298317 doi "https://doi.org/10.1289/ehp.9337" @default.
• W1976298317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1626396" @default.
• W1976298317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17035140" @default.
• W1976298317 hasPublicationYear "2006" @default.
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