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• W1976299315 endingPage "140" @default.
• W1976299315 startingPage "133" @default.
• W1976299315 abstract "Echinocandins are a novel class of antifungal drugs. They have good activity against Candida spp and Aspergillus spp. Their low selective toxicity allows their administration at high doses with few secondary side effects. We have reviewed the available data on the endpoints for these drugs in their in vitro susceptibility testing on yeasts and moulds. The microdilution broth method is the most commonly used technique and MIC-1 (80% of growth inhibition) seems to be the most reliable endpoint when yeasts are tested. This endpoint also seems to be the most appropriate for the different drugs when they are combined with echinocandins using the checkerboard method for testing yeasts. By contrast, in the case of moulds, the minimum effective concentration (MEC) correlates better with the in vivo activity than the MIC when echinocandins are tested, and when these drugs are combined with other antifungals, MIC-2 (50% of growth inhibition) seems the most appropriate endpoint. Criteria based on drug pharmacodynamics is the most useful to define the echinocandin endpoints that best correlate with their in vivo efficacy." @default.
• W1976299315 created "2016-06-24" @default.
• W1976299315 creator A5036496473 @default.
• W1976299315 creator A5091228194 @default.
• W1976299315 date "2005-09-01" @default.
• W1976299315 modified "2023-10-03" @default.
• W1976299315 title "Actividad in vitro de las equinocandinas ¿Cómo debe evaluarse?" @default.
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• W1976299315 doi "https://doi.org/10.1016/s1130-1406(05)70026-7" @default.
• W1976299315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16309347" @default.
• W1976299315 hasPublicationYear "2005" @default.

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