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- W1976301278 abstract "Prosaposin, the precursor of the sphingolipid hydrolase activator proteins called saposins A, B, C, and D, is abundant in the nervous system and muscles. Besides its role as the precursor of saposins, prosaposin is reported to function as a neurotrophic factor, initiating neural differentiation and preventing neuronal cell death in vivo and in vitro. In this study, we examined the localization and synthesis of prosaposin in the rat cochlea. Intense prosaposin immunoreactivity was observed in the organ of Corti, stria vascularis, and spiral ganglion. In an immuno-electron microscopic study, prosaposin immunoreactivity was found mainly in lysosomal granules of the cells in these regions. In the lysosome, prosaposin does not always colocalize with cathepsin D, but was localized mainly in the dark area of the lysosome. Prosaposin mRNA was observed in these same regions. Our results suggest that prosaposin plays a role in homeostasis in the peripheral auditory system." @default.
- W1976301278 created "2016-06-24" @default.
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- W1976301278 date "1997-01-01" @default.
- W1976301278 modified "2023-09-26" @default.
- W1976301278 title "1236 Neurotrophic activity of prosaposin 18-mer peptide fragment" @default.
- W1976301278 doi "https://doi.org/10.1016/s0168-0102(97)90430-2" @default.
- W1976301278 hasPublicationYear "1997" @default.
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