FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976314139> ?p ?o ?g. }

• W1976314139 endingPage "874" @default.
• W1976314139 startingPage "865" @default.
• W1976314139 abstract "The role of H2O2 as a second messenger in signal transduction pathways is well established. We show here that the NADPH oxidase-dependent production of and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1). ASK1 binds only to the reduced form of thioredoxin (Trx). ADP induced the dissociation of ASK1/Trx complex and thus resulted in ASK1 activation, as assessed by phosphorylation at Thr845, which was enhanced after treatment with aurothioglucose (ATG), an inhibitor of Trx reductase. While dissociation of the complex implies Trx oxidation, protein electrophoretic mobility shift assay detected oxidation of Trx only after bolus H2O2 but not after ADP stimulation. These results demonstrate that the ADP-stimulated respiratory burst activated the ASK1–MKK4–JNK1/c-Jun signaling pathway in AM and suggest that transient and localized oxidation of Trx by the NADPH oxidase-mediated generation of H2O2 may play a critical role in ASK1 activation and the inflammatory response." @default.
• W1976314139 created "2016-06-24" @default.
• W1976314139 creator A5008608269 @default.
• W1976314139 creator A5016294535 @default.
• W1976314139 creator A5022475053 @default.
• W1976314139 creator A5040372208 @default.
• W1976314139 creator A5043578477 @default.
• W1976314139 creator A5062198021 @default.
• W1976314139 creator A5078825783 @default.
• W1976314139 date "2006-01-01" @default.
• W1976314139 modified "2023-09-27" @default.
• W1976314139 title "The Adp-stimulated Nadph Oxidase Activates The Ask-1/mkk4/jnk Pathway In Alveolar Macrophages" @default.
• W1976314139 cites W1481679469 @default.
• W1976314139 cites W1555905413 @default.
• W1976314139 cites W1613287901 @default.
• W1976314139 cites W1932728046 @default.
• W1976314139 cites W1949973946 @default.
• W1976314139 cites W1965167661 @default.
• W1976314139 cites W1969268163 @default.
• W1976314139 cites W1969419810 @default.
• W1976314139 cites W1970328728 @default.
• W1976314139 cites W1970420221 @default.
• W1976314139 cites W1970807482 @default.
• W1976314139 cites W1987621178 @default.
• W1976314139 cites W1988656758 @default.
• W1976314139 cites W1989957948 @default.
• W1976314139 cites W1991044190 @default.
• W1976314139 cites W1992101010 @default.
• W1976314139 cites W1993397245 @default.
• W1976314139 cites W1994101634 @default.
• W1976314139 cites W1994219871 @default.
• W1976314139 cites W1998411300 @default.
• W1976314139 cites W1998571837 @default.
• W1976314139 cites W2005341765 @default.
• W1976314139 cites W2006772108 @default.
• W1976314139 cites W2007458764 @default.
• W1976314139 cites W2008144053 @default.
• W1976314139 cites W2008820074 @default.
• W1976314139 cites W2008872627 @default.
• W1976314139 cites W2010845266 @default.
• W1976314139 cites W2012357103 @default.
• W1976314139 cites W2019650684 @default.
• W1976314139 cites W2032824681 @default.
• W1976314139 cites W2033712553 @default.
• W1976314139 cites W2033961385 @default.
• W1976314139 cites W2034580062 @default.
• W1976314139 cites W2040332703 @default.
• W1976314139 cites W2047455844 @default.
• W1976314139 cites W2048486951 @default.
• W1976314139 cites W2050326353 @default.
• W1976314139 cites W2053909759 @default.
• W1976314139 cites W2054590225 @default.
• W1976314139 cites W2059700063 @default.
• W1976314139 cites W2067201145 @default.
• W1976314139 cites W2068976530 @default.
• W1976314139 cites W2072963191 @default.
• W1976314139 cites W2073913852 @default.
• W1976314139 cites W2075584603 @default.
• W1976314139 cites W2088411222 @default.
• W1976314139 cites W2102258234 @default.
• W1976314139 cites W2102619095 @default.
• W1976314139 cites W2103650142 @default.
• W1976314139 cites W2104836622 @default.
• W1976314139 cites W2104896634 @default.
• W1976314139 cites W2106171481 @default.
• W1976314139 cites W2110361956 @default.
• W1976314139 cites W2116938728 @default.
• W1976314139 cites W2118808586 @default.
• W1976314139 cites W2123085934 @default.
• W1976314139 cites W2123333594 @default.
• W1976314139 cites W2124606330 @default.
• W1976314139 cites W2125570177 @default.
• W1976314139 cites W2128635872 @default.
• W1976314139 cites W2130191536 @default.
• W1976314139 cites W2137122673 @default.
• W1976314139 cites W2141802124 @default.
• W1976314139 cites W2145220191 @default.
• W1976314139 cites W2147309521 @default.
• W1976314139 cites W2150081412 @default.
• W1976314139 cites W2150291597 @default.
• W1976314139 cites W2156419840 @default.
• W1976314139 cites W2159574886 @default.
• W1976314139 cites W2165301262 @default.
• W1976314139 cites W2192080449 @default.
• W1976314139 cites W2327290508 @default.
• W1976314139 cites W4293247451 @default.
• W1976314139 cites W66129143 @default.
• W1976314139 doi "https://doi.org/10.1080/10715760600758514" @default.
• W1976314139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713795" @default.
• W1976314139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17015265" @default.
• W1976314139 hasPublicationYear "2006" @default.
• W1976314139 type Work @default.
• W1976314139 sameAs 1976314139 @default.
• W1976314139 citedByCount "56" @default.
• W1976314139 countsByYear W19763141392012 @default.
• W1976314139 countsByYear W19763141392013 @default.
• W1976314139 countsByYear W19763141392014 @default.
• W1976314139 countsByYear W19763141392015 @default.

• next