FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976315390> ?p ?o ?g. }

• W1976315390 abstract "New dienophiles, dimethyl acetoxymethylenemalonate and its analogues, have been synthesized. These dienophiles reacted with cyclopentadiene to give Diels-Alder adducts, which served as versatile synthetic precursors for carbocyclic C-nucleosides. The method has the following three characteristics: (1) the C-C bond in the adduct originated from the dienophile can be cleaved stereoselectively by the reductive retrograde aldol (RRA) reaction, (2) the CC bond in the adduct serves as a latent functionality of 2′- and 3′- positions of the nucleoside, and (3) the malonate unit can be transformed to a variety of heterocycles. The high pressure mediated Diels-Alder reaction of furan with the same dienophiles also gave the cycloadducts, which served as synthons for C-nucleosides. Use of chiral dienophiles, such as di-1-menthyl acetoxymethylenemalonate, for the above Diels-Alder reactions has offered a new route to the enantioselective synthesis of C-nucleosides and their carbocyclic analogues. Essentially the same methodology has also been applied to the synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]hept-5-en-3-one, in which a reductive amido bond cleavage reaction similar to (1) is involved. Synthesis of carbocyclic oxetanocin and its analogues is also described." @default.
• W1976315390 created "2016-06-24" @default.
• W1976315390 creator A5005079654 @default.
• W1976315390 creator A5021222679 @default.
• W1976315390 creator A5043121221 @default.
• W1976315390 creator A5064221710 @default.
• W1976315390 date "1991-01-01" @default.
• W1976315390 modified "2023-10-05" @default.
• W1976315390 title "A New Method for the Stereoselective Synthesis of Nucleosides by Means of Sodium Borohydride Mediated Reductive C-C or C-N Bond Cleavage Reaction" @default.
• W1976315390 cites W1481284080 @default.
• W1976315390 cites W1485594602 @default.
• W1976315390 cites W1488837325 @default.
• W1976315390 cites W1495092171 @default.
• W1976315390 cites W1509029272 @default.
• W1976315390 cites W1564368218 @default.
• W1976315390 cites W178253875 @default.
• W1976315390 cites W1972450367 @default.
• W1976315390 cites W1979416940 @default.
• W1976315390 cites W1980990875 @default.
• W1976315390 cites W1983000163 @default.
• W1976315390 cites W1983815903 @default.
• W1976315390 cites W1984101023 @default.
• W1976315390 cites W1987194550 @default.
• W1976315390 cites W1990524257 @default.
• W1976315390 cites W1991160902 @default.
• W1976315390 cites W1998498230 @default.
• W1976315390 cites W1998623502 @default.
• W1976315390 cites W1999069778 @default.
• W1976315390 cites W1999909183 @default.
• W1976315390 cites W2002322147 @default.
• W1976315390 cites W2005954288 @default.
• W1976315390 cites W2006461616 @default.
• W1976315390 cites W2009125123 @default.
• W1976315390 cites W2013380552 @default.
• W1976315390 cites W2013666384 @default.
• W1976315390 cites W2029416088 @default.
• W1976315390 cites W2030069590 @default.
• W1976315390 cites W2034451071 @default.
• W1976315390 cites W2036017684 @default.
• W1976315390 cites W2036545996 @default.
• W1976315390 cites W2039317889 @default.
• W1976315390 cites W2039811047 @default.
• W1976315390 cites W2041166015 @default.
• W1976315390 cites W2044102753 @default.
• W1976315390 cites W2059784335 @default.
• W1976315390 cites W2063997305 @default.
• W1976315390 cites W2067031793 @default.
• W1976315390 cites W2067073728 @default.
• W1976315390 cites W2070799290 @default.
• W1976315390 cites W2082062589 @default.
• W1976315390 cites W2082813712 @default.
• W1976315390 cites W2088244926 @default.
• W1976315390 cites W2089919637 @default.
• W1976315390 cites W2092794978 @default.
• W1976315390 cites W2110881022 @default.
• W1976315390 cites W2111113550 @default.
• W1976315390 cites W2139077383 @default.
• W1976315390 cites W2140257042 @default.
• W1976315390 cites W2147693173 @default.
• W1976315390 cites W2166594602 @default.
• W1976315390 cites W2312559223 @default.
• W1976315390 cites W2314110063 @default.
• W1976315390 cites W2315252826 @default.
• W1976315390 cites W2315413551 @default.
• W1976315390 cites W2315429620 @default.
• W1976315390 cites W2320470238 @default.
• W1976315390 cites W2320576030 @default.
• W1976315390 cites W2322817580 @default.
• W1976315390 cites W2325927773 @default.
• W1976315390 cites W2326943078 @default.
• W1976315390 cites W2328038041 @default.
• W1976315390 cites W2331821336 @default.
• W1976315390 cites W2332314956 @default.
• W1976315390 cites W2949996377 @default.
• W1976315390 cites W2952203034 @default.
• W1976315390 cites W2952390601 @default.
• W1976315390 cites W4211254635 @default.
• W1976315390 cites W4238307495 @default.
• W1976315390 cites W597995169 @default.
• W1976315390 doi "https://doi.org/10.1002/ijch.199100029" @default.
• W1976315390 hasPublicationYear "1991" @default.
• W1976315390 type Work @default.
• W1976315390 sameAs 1976315390 @default.
• W1976315390 citedByCount "8" @default.
• W1976315390 crossrefType "journal-article" @default.
• W1976315390 hasAuthorship W1976315390A5005079654 @default.
• W1976315390 hasAuthorship W1976315390A5021222679 @default.
• W1976315390 hasAuthorship W1976315390A5043121221 @default.
• W1976315390 hasAuthorship W1976315390A5064221710 @default.
• W1976315390 hasConcept C127413603 @default.
• W1976315390 hasConcept C155647269 @default.
• W1976315390 hasConcept C161790260 @default.
• W1976315390 hasConcept C175156509 @default.
• W1976315390 hasConcept C178790620 @default.
• W1976315390 hasConcept C181647583 @default.
• W1976315390 hasConcept C185592680 @default.
• W1976315390 hasConcept C187320778 @default.
• W1976315390 hasConcept C21951064 @default.
• W1976315390 hasConcept C2780048404 @default.
• W1976315390 hasConcept C3044715 @default.

• next