FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976320302> ?p ?o ?g. }

• W1976320302 endingPage "H2414" @default.
• W1976320302 startingPage "H2409" @default.
• W1976320302 abstract "The gaseous compound carbon monoxide (CO) has been identified as an important endogenous biological messenger in brain and is a major component in regulation of cerebrovascular circulation in newborns. CO is produced endogenously by catabolism of heme to CO, free iron, and biliverdin during enzymatic degradation of heme by heme oxygenase (HO). The present study was designed to test the hypothesis that endogenously produced CO contributes to hypotension-induced vasodilation of cerebral arterioles. Experiments used anesthetized piglets with implanted, closed cranial windows. Topical application of the HO substrate heme-l-lysinate caused dilation of pial arterioles that was blocked by a metal porphyrin inhibitor of HO, chromium mesoporphyrin (CrMP). In normotensive piglets (arterial pressure 64 +/- 4 mmHg), CrMP did not cause vasoconstriction of pial arterioles but rather a transient dilation. Hypotension (50% of basal blood pressure) increased cerebral CO production and dilated pial arterioles from 66 +/- 2 to 92 +/- 7 microm. In hypotensive piglets, topical CrMP or intravenous tin protoporphyrin decreased cerebral CO production and produced pial arteriolar constriction to normotensive diameters. In additional experiments, because prostacyclin and nitric oxide (NO) are also key dilators that can contribute to cerebrovascular dilation, we held their levels constant. NO/prostacyclin clamp was accomplished with continuous, simultaneous application of indomethacin, N(omega)-nitro-l-arginine, and minimal dilatory concentrations of iloprost and sodium nitroprusside. With constant NO and prostacyclin, the transient dilator and prolonged constrictor responses to CrMP of normotensive and hypotensive piglets, respectively, were the same as when NO and prostaglandins were not held constant. These data suggest that endogenously produced CO contributes to cerebrovascular dilation in response to reduced perfusion pressure." @default.
• W1976320302 created "2016-06-24" @default.
• W1976320302 creator A5010883315 @default.
• W1976320302 creator A5038929454 @default.
• W1976320302 creator A5055369902 @default.
• W1976320302 date "2006-11-01" @default.
• W1976320302 modified "2023-09-24" @default.
• W1976320302 title "Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets" @default.
• W1976320302 cites W1766573027 @default.
• W1976320302 cites W1812961065 @default.
• W1976320302 cites W1884656506 @default.
• W1976320302 cites W1906281300 @default.
• W1976320302 cites W1971953739 @default.
• W1976320302 cites W1978314464 @default.
• W1976320302 cites W1978492141 @default.
• W1976320302 cites W1994780702 @default.
• W1976320302 cites W1999712695 @default.
• W1976320302 cites W2016956820 @default.
• W1976320302 cites W2028136904 @default.
• W1976320302 cites W2028533213 @default.
• W1976320302 cites W2052374786 @default.
• W1976320302 cites W2054807014 @default.
• W1976320302 cites W2067280621 @default.
• W1976320302 cites W2087516645 @default.
• W1976320302 cites W2093205075 @default.
• W1976320302 cites W2093501510 @default.
• W1976320302 cites W2105018588 @default.
• W1976320302 cites W2108463035 @default.
• W1976320302 cites W2117847926 @default.
• W1976320302 cites W2118915561 @default.
• W1976320302 cites W2120529833 @default.
• W1976320302 cites W2124174923 @default.
• W1976320302 cites W2145530136 @default.
• W1976320302 cites W2146607440 @default.
• W1976320302 cites W2153491246 @default.
• W1976320302 cites W2166085728 @default.
• W1976320302 cites W2168559229 @default.
• W1976320302 cites W2169037315 @default.
• W1976320302 cites W2178628225 @default.
• W1976320302 cites W2205085234 @default.
• W1976320302 cites W2240089866 @default.
• W1976320302 cites W2327792810 @default.
• W1976320302 cites W2345995726 @default.
• W1976320302 cites W2414478847 @default.
• W1976320302 cites W2417859282 @default.
• W1976320302 cites W2465702003 @default.
• W1976320302 cites W2470690224 @default.
• W1976320302 cites W2472000854 @default.
• W1976320302 cites W285469281 @default.
• W1976320302 doi "https://doi.org/10.1152/ajpheart.01368.2005" @default.
• W1976320302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1593219" @default.
• W1976320302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16751286" @default.
• W1976320302 hasPublicationYear "2006" @default.
• W1976320302 type Work @default.
• W1976320302 sameAs 1976320302 @default.
• W1976320302 citedByCount "34" @default.
• W1976320302 countsByYear W19763203022012 @default.
• W1976320302 countsByYear W19763203022014 @default.
• W1976320302 countsByYear W19763203022015 @default.
• W1976320302 countsByYear W19763203022017 @default.
• W1976320302 countsByYear W19763203022018 @default.
• W1976320302 countsByYear W19763203022019 @default.
• W1976320302 countsByYear W19763203022020 @default.
• W1976320302 countsByYear W19763203022021 @default.
• W1976320302 countsByYear W19763203022023 @default.
• W1976320302 crossrefType "journal-article" @default.
• W1976320302 hasAuthorship W1976320302A5010883315 @default.
• W1976320302 hasAuthorship W1976320302A5038929454 @default.
• W1976320302 hasAuthorship W1976320302A5055369902 @default.
• W1976320302 hasBestOaLocation W19763203022 @default.
• W1976320302 hasConcept C119671327 @default.
• W1976320302 hasConcept C120770815 @default.
• W1976320302 hasConcept C126322002 @default.
• W1976320302 hasConcept C12722491 @default.
• W1976320302 hasConcept C134018914 @default.
• W1976320302 hasConcept C181199279 @default.
• W1976320302 hasConcept C185592680 @default.
• W1976320302 hasConcept C2776217839 @default.
• W1976320302 hasConcept C2777032099 @default.
• W1976320302 hasConcept C2779219270 @default.
• W1976320302 hasConcept C2779482390 @default.
• W1976320302 hasConcept C2779961880 @default.
• W1976320302 hasConcept C2781128415 @default.
• W1976320302 hasConcept C42219234 @default.
• W1976320302 hasConcept C519581460 @default.
• W1976320302 hasConcept C55493867 @default.
• W1976320302 hasConcept C71924100 @default.
• W1976320302 hasConcept C98274493 @default.
• W1976320302 hasConceptScore W1976320302C119671327 @default.
• W1976320302 hasConceptScore W1976320302C120770815 @default.
• W1976320302 hasConceptScore W1976320302C126322002 @default.
• W1976320302 hasConceptScore W1976320302C12722491 @default.
• W1976320302 hasConceptScore W1976320302C134018914 @default.
• W1976320302 hasConceptScore W1976320302C181199279 @default.
• W1976320302 hasConceptScore W1976320302C185592680 @default.
• W1976320302 hasConceptScore W1976320302C2776217839 @default.
• W1976320302 hasConceptScore W1976320302C2777032099 @default.
• W1976320302 hasConceptScore W1976320302C2779219270 @default.

• next