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- W1976320412 abstract "In Brief Objective. To establish diagnostic accuracy and reproducibility of a diagnosis of cervical intraepithelial neoplasia 3 (CIN 3) in menopausal women on routinely stained hematoxylin and eosin (H&E) slides and compare it to slides processed for p16 and Ki-67. Materials and Methods. Confirmed cases of CIN 3 and benign atrophic changes were reviewed independently by 4 pathologists. The samples were studied on separate occasions using H&E staining, p16, and Ki-67. Differences in sensitivity and specificity between reviewers or methods were tested for significance using the McNemar test, whereas differences in positive and negative predictive values were tested for significance using a marginal probability generalized linear model for agreement. Results. Sensitivity was high for H&E (93.3%-100%) and Ki-67 (93.3%-100%) and lower for p16 (70.0%-90.0%). Intraobserver variability was also lower for p16 (76.7% vs 90.0%, although this difference was not statistically significant, p = .219). p16 agreement, however, for CIN 3 is significantly lower than that for atrophy (76.7% vs 97.4%, p = .018). Conclusions. Routine histopathologic diagnosis of CIN 3 in menopausal women is highly accurate and reproducible. Both H&E and Ki-67 are useful immunohistochemical stains in helping differentiate atrophy from high-grade cervical intraepithelial lesions in postmenopausal cervical biopsies. There may be more disagreement among readers using p16. The diagnosis of CIN 3 in menopausal women is as accurate and reproducible using H&E as it is with Ki-67 and p16." @default.
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- W1976320412 date "2010-04-01" @default.
- W1976320412 modified "2023-09-22" @default.
- W1976320412 title "Diagnostic Reproducibility of Cervical Intraepithelial Neoplasia 3 and Atrophy in Menopausal Women on Hematoxylin and Eosin, Ki-67, and p16 Stained Slides" @default.
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- W1976320412 doi "https://doi.org/10.1097/lgt.0b013e3181bcdc35" @default.
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