FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976323650> ?p ?o ?g. }

• W1976323650 endingPage "1117" @default.
• W1976323650 startingPage "1112" @default.
• W1976323650 abstract "We studied the mechanisms by which oral or intravenous administration of allogeneic splenocytes prevents sensitization by skin allografts and development of accelerated rejection of subsequent cardiac allografts. LEW rats were sensitized with BN skin allografts 7 days prior to receiving heterotopic (LEW x BN)F1 vascularized cardiac allografts. While unsensitized cardiac allografts are rejected on days 6-8, control sensitized grafts were rejected within 24 to 48 hr. Oral administration of BN splenocytes during the sensitization phase (between skin and heart grafting) has been found to prevent accelerated allograft rejection and prolong cardiac allograft survival to 7 days. An alternative route of antigen exposure, specifically intravenous administration of BN splenocytes (50 x 10(6) daily for 5 days starting on the day of skin grafting), also prevented accelerated cardiac allograft rejection and prolonged allograft survival to 9 +/- 1 days (n = 5). Immunoperoxidase studies of cardiac allografts harvested 24-48 hr posttransplant showed that, when compared with sensitized controls, animals that received oral splenocytes had reduced deposition of IgG (end-point titer of 1/1000 vs. 1/4000), IgM (1/1000 vs. 1/16000), C3 (1/4000 vs. 1/16000), and fibrin (1/4000 vs. 1/16000). There was also decreased infiltration by macrophages (18 +/- 8 vs. 37 +/- 8 cells/HPF, P < 0.01), T cells (5 +/- 3 vs. 19 +/- 7, P < 0.01), and IL-2R+ T cells (5 +/- 3 vs. 15 +/- 4, P < 0.01), and a significant reduction in the numbers and extent of intragraft mononuclear cells stained with antibodies to IL-1, IL-2, IL-6, IL-8, IFN-gamma, and TNF-alpha. In contrast, these grafts showed markedly increased IL-4 staining (including most mononuclear and all endothelial cells), as compared with control grafts (< 20% of mononuclear cells and only focal endothelial staining). Immunoperoxidase studies of cardiac allografts harvested from rats receiving intravenous splenocytes also showed markedly reduced humoral deposits and cellular infiltrates, comparable to that found in the oral splenocytes-treated group, but showed significantly different cytokine expression. In particular, some intragraft mononuclear cell labeling for IFN-gamma remained, and IL-4 staining was not increased relative to control grafts. Attempts were then made to abrogate spleen cell-induced prolongation of cardiac allograft survival by daily injections of CD4 monoclonal antibody (BWH-4 mAb, 700 micrograms) from the time of cardiac transplantation, therapy previously shown unable to prolong cardiac survival in this model when commenced after skin graft-induced sensitization has occurred.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W1976323650 created "2016-06-24" @default.
• W1976323650 creator A5004954227 @default.
• W1976323650 creator A5028211848 @default.
• W1976323650 creator A5047555474 @default.
• W1976323650 creator A5067268055 @default.
• W1976323650 creator A5069092257 @default.
• W1976323650 date "1993-05-01" @default.
• W1976323650 modified "2023-09-26" @default.
• W1976323650 title "ORAL, BUT NOT INTRAVENOUS, ALLOANTIGEN PREVENTS ACCELERATED ALLOGRAFT REJECTION BY SELECTIVE INTRAGRAFT TH2 CELL ACTIVATION" @default.
• W1976323650 doi "https://doi.org/10.1097/00007890-199305000-00034" @default.
• W1976323650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8497891" @default.
• W1976323650 hasPublicationYear "1993" @default.
• W1976323650 type Work @default.
• W1976323650 sameAs 1976323650 @default.
• W1976323650 citedByCount "119" @default.
• W1976323650 countsByYear W19763236502012 @default.
• W1976323650 countsByYear W19763236502013 @default.
• W1976323650 countsByYear W19763236502014 @default.
• W1976323650 countsByYear W19763236502017 @default.
• W1976323650 countsByYear W19763236502019 @default.
• W1976323650 crossrefType "journal-article" @default.
• W1976323650 hasAuthorship W1976323650A5004954227 @default.
• W1976323650 hasAuthorship W1976323650A5028211848 @default.
• W1976323650 hasAuthorship W1976323650A5047555474 @default.
• W1976323650 hasAuthorship W1976323650A5067268055 @default.
• W1976323650 hasAuthorship W1976323650A5069092257 @default.
• W1976323650 hasBestOaLocation W19763236501 @default.
• W1976323650 hasConcept C126322002 @default.
• W1976323650 hasConcept C159654299 @default.
• W1976323650 hasConcept C16685009 @default.
• W1976323650 hasConcept C167464567 @default.
• W1976323650 hasConcept C189976730 @default.
• W1976323650 hasConcept C203014093 @default.
• W1976323650 hasConcept C2776217527 @default.
• W1976323650 hasConcept C2778849806 @default.
• W1976323650 hasConcept C2911091166 @default.
• W1976323650 hasConcept C54173615 @default.
• W1976323650 hasConcept C71924100 @default.
• W1976323650 hasConceptScore W1976323650C126322002 @default.
• W1976323650 hasConceptScore W1976323650C159654299 @default.
• W1976323650 hasConceptScore W1976323650C16685009 @default.
• W1976323650 hasConceptScore W1976323650C167464567 @default.
• W1976323650 hasConceptScore W1976323650C189976730 @default.
• W1976323650 hasConceptScore W1976323650C203014093 @default.
• W1976323650 hasConceptScore W1976323650C2776217527 @default.
• W1976323650 hasConceptScore W1976323650C2778849806 @default.
• W1976323650 hasConceptScore W1976323650C2911091166 @default.
• W1976323650 hasConceptScore W1976323650C54173615 @default.
• W1976323650 hasConceptScore W1976323650C71924100 @default.
• W1976323650 hasIssue "5" @default.
• W1976323650 hasLocation W19763236501 @default.
• W1976323650 hasLocation W19763236502 @default.
• W1976323650 hasLocation W19763236503 @default.
• W1976323650 hasOpenAccess W1976323650 @default.
• W1976323650 hasPrimaryLocation W19763236501 @default.
• W1976323650 hasRelatedWork W1525217876 @default.
• W1976323650 hasRelatedWork W1963647909 @default.
• W1976323650 hasRelatedWork W1976323650 @default.
• W1976323650 hasRelatedWork W2005623473 @default.
• W1976323650 hasRelatedWork W2101855152 @default.
• W1976323650 hasRelatedWork W2110776901 @default.
• W1976323650 hasRelatedWork W2383591694 @default.
• W1976323650 hasRelatedWork W2437832493 @default.
• W1976323650 hasRelatedWork W2576837937 @default.
• W1976323650 hasRelatedWork W3108133308 @default.
• W1976323650 hasVolume "55" @default.
• W1976323650 isParatext "false" @default.
• W1976323650 isRetracted "false" @default.
• W1976323650 magId "1976323650" @default.
• W1976323650 workType "article" @default.