Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976331259> ?p ?o ?g. }
- W1976331259 endingPage "1250" @default.
- W1976331259 startingPage "1243" @default.
- W1976331259 abstract "Abstract— Synaptosomal release and exchange of [3H]GABA were studied by a superfusion technique which minimizes reuptake. The release of [3H]GABA was increased by depolarizing concentrations of KCl and showed calcium-dependence. Superfusion with 1-1000 μm unlabelled GABA caused a dose dependent, saturable increase in the release of radioactivity by homoexchange. The exchange process showed high substrate specificity: among the various amino acids and putative neurotransmitters tested, only γ-amino-β-hydroxybutyric acid was a good stimulator of [3H]GABA release. Superfusion with sodium-free medium (NaCl replaced by sucrose) virtually abolished homoexchange. Ouabain also increased the release of [3H]GABA, and its action was additive to that of unlabelled GABA. The presence of exchange at concentrations that are in the range of the high affinity uptake system, the apparent similarity between calculated rates of exchange and initial uptake rates, the non-detectability of exchange in a condition (Na+ deprivation) which inhibits high affinity uptake, and the lack of decrease of actual GABA concentration in incubation media used for uptake experiments, all suggest that homoexchange accounts for a substantial part of the synaptosomal accumulation of [3H]GABA generally interpreted as high affinity uptake." @default.
- W1976331259 created "2016-06-24" @default.
- W1976331259 creator A5014488911 @default.
- W1976331259 creator A5015779278 @default.
- W1976331259 creator A5077011667 @default.
- W1976331259 creator A5081494062 @default.
- W1976331259 date "1975-06-01" @default.
- W1976331259 modified "2023-10-18" @default.
- W1976331259 title "RELEASE AND EXCHANGE STUDIES RELATING TO THE SYNAPTOSOMAL UPTAKE OF GABA" @default.
- W1976331259 cites W1963485323 @default.
- W1976331259 cites W1972846467 @default.
- W1976331259 cites W1986227671 @default.
- W1976331259 cites W1990631513 @default.
- W1976331259 cites W1991097268 @default.
- W1976331259 cites W1991806476 @default.
- W1976331259 cites W1996861956 @default.
- W1976331259 cites W2001653062 @default.
- W1976331259 cites W2002865586 @default.
- W1976331259 cites W2005884659 @default.
- W1976331259 cites W2007831432 @default.
- W1976331259 cites W2012341560 @default.
- W1976331259 cites W2019657369 @default.
- W1976331259 cites W2020335228 @default.
- W1976331259 cites W2028938152 @default.
- W1976331259 cites W2029501548 @default.
- W1976331259 cites W2036427763 @default.
- W1976331259 cites W2037179530 @default.
- W1976331259 cites W2042483170 @default.
- W1976331259 cites W2042717783 @default.
- W1976331259 cites W2042765535 @default.
- W1976331259 cites W2043528945 @default.
- W1976331259 cites W2045094409 @default.
- W1976331259 cites W2052148365 @default.
- W1976331259 cites W2059484913 @default.
- W1976331259 cites W2069034440 @default.
- W1976331259 cites W2076232612 @default.
- W1976331259 cites W2077708538 @default.
- W1976331259 cites W2084971405 @default.
- W1976331259 cites W2088074422 @default.
- W1976331259 cites W2088647176 @default.
- W1976331259 cites W2089078716 @default.
- W1976331259 cites W2092065659 @default.
- W1976331259 cites W2095036259 @default.
- W1976331259 cites W2122766752 @default.
- W1976331259 cites W2163529705 @default.
- W1976331259 cites W2984223094 @default.
- W1976331259 cites W4252517265 @default.
- W1976331259 cites W98057812 @default.
- W1976331259 doi "https://doi.org/10.1111/j.1471-4159.1975.tb03905.x" @default.
- W1976331259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1127436" @default.
- W1976331259 hasPublicationYear "1975" @default.
- W1976331259 type Work @default.
- W1976331259 sameAs 1976331259 @default.
- W1976331259 citedByCount "116" @default.
- W1976331259 countsByYear W19763312592016 @default.
- W1976331259 crossrefType "journal-article" @default.
- W1976331259 hasAuthorship W1976331259A5014488911 @default.
- W1976331259 hasAuthorship W1976331259A5015779278 @default.
- W1976331259 hasAuthorship W1976331259A5077011667 @default.
- W1976331259 hasAuthorship W1976331259A5081494062 @default.
- W1976331259 hasConcept C12554922 @default.
- W1976331259 hasConcept C126322002 @default.
- W1976331259 hasConcept C134018914 @default.
- W1976331259 hasConcept C170493617 @default.
- W1976331259 hasConcept C178790620 @default.
- W1976331259 hasConcept C185592680 @default.
- W1976331259 hasConcept C202751555 @default.
- W1976331259 hasConcept C25642318 @default.
- W1976331259 hasConcept C2775864247 @default.
- W1976331259 hasConcept C2778921374 @default.
- W1976331259 hasConcept C2779133857 @default.
- W1976331259 hasConcept C515207424 @default.
- W1976331259 hasConcept C519063684 @default.
- W1976331259 hasConcept C537181965 @default.
- W1976331259 hasConcept C55493867 @default.
- W1976331259 hasConcept C71924100 @default.
- W1976331259 hasConcept C86803240 @default.
- W1976331259 hasConcept C99631742 @default.
- W1976331259 hasConceptScore W1976331259C12554922 @default.
- W1976331259 hasConceptScore W1976331259C126322002 @default.
- W1976331259 hasConceptScore W1976331259C134018914 @default.
- W1976331259 hasConceptScore W1976331259C170493617 @default.
- W1976331259 hasConceptScore W1976331259C178790620 @default.
- W1976331259 hasConceptScore W1976331259C185592680 @default.
- W1976331259 hasConceptScore W1976331259C202751555 @default.
- W1976331259 hasConceptScore W1976331259C25642318 @default.
- W1976331259 hasConceptScore W1976331259C2775864247 @default.
- W1976331259 hasConceptScore W1976331259C2778921374 @default.
- W1976331259 hasConceptScore W1976331259C2779133857 @default.
- W1976331259 hasConceptScore W1976331259C515207424 @default.
- W1976331259 hasConceptScore W1976331259C519063684 @default.
- W1976331259 hasConceptScore W1976331259C537181965 @default.
- W1976331259 hasConceptScore W1976331259C55493867 @default.
- W1976331259 hasConceptScore W1976331259C71924100 @default.
- W1976331259 hasConceptScore W1976331259C86803240 @default.
- W1976331259 hasConceptScore W1976331259C99631742 @default.
- W1976331259 hasIssue "6" @default.
- W1976331259 hasLocation W19763312591 @default.