FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976335644> ?p ?o ?g. }

• W1976335644 endingPage "1449" @default.
• W1976335644 startingPage "1441" @default.
• W1976335644 abstract "Repair of injured skeletal muscle by cell therapies has been limited by poor survival of injected cells. Use of a carrier scaffold delivering cells locally, may enhance in vivo cell survival, and promote skeletal muscle regeneration. Biomaterial scaffolds are often implanted into muscle tissue through invasive surgeries, which can result in trauma that delays healing. Minimally invasive approaches to scaffold implantation are thought to minimize these adverse effects. This hypothesis was addressed in the context of a severe mouse skeletal muscle injury model. A degradable, shape-memory alginate scaffold that was highly porous and compressible was delivered by minimally invasive surgical techniques to injured tibialis anterior muscle. The scaffold controlled was quickly rehydrated in situ with autologous myoblasts and growth factors (either insulin-like growth factor-1 (IGF-1) alone or IGF-1 with vascular endothelial growth factor (VEGF)). The implanted scaffolds delivering myoblasts and IGF-1 significantly reduced scar formation, enhanced cell engraftment, and improved muscle contractile function. The addition of VEGF to the scaffold further improved functional recovery likely through increased angiogenesis. Thus, the delivery of myoblasts and dual local release of VEGF and IGF-1 from degradable scaffolds implanted through a minimally invasive procedure effectively promoted the functional regeneration of injured skeletal muscle." @default.
• W1976335644 created "2016-06-24" @default.
• W1976335644 creator A5001336137 @default.
• W1976335644 creator A5031287763 @default.
• W1976335644 creator A5047797435 @default.
• W1976335644 creator A5053275663 @default.
• W1976335644 creator A5055292026 @default.
• W1976335644 creator A5057019311 @default.
• W1976335644 date "2014-08-01" @default.
• W1976335644 modified "2023-10-11" @default.
• W1976335644 title "Minimally Invasive Approach to the Repair of Injured Skeletal Muscle With a Shape-memory Scaffold" @default.
• W1976335644 cites W1809073012 @default.
• W1976335644 cites W1968814074 @default.
• W1976335644 cites W1970576706 @default.
• W1976335644 cites W1972875347 @default.
• W1976335644 cites W1990344639 @default.
• W1976335644 cites W1999490106 @default.
• W1976335644 cites W2000292756 @default.
• W1976335644 cites W2005361843 @default.
• W1976335644 cites W2007398635 @default.
• W1976335644 cites W2012400991 @default.
• W1976335644 cites W2012672540 @default.
• W1976335644 cites W2013732980 @default.
• W1976335644 cites W2014077602 @default.
• W1976335644 cites W2016008242 @default.
• W1976335644 cites W2016325063 @default.
• W1976335644 cites W2017429680 @default.
• W1976335644 cites W2020472115 @default.
• W1976335644 cites W2036937290 @default.
• W1976335644 cites W2047866615 @default.
• W1976335644 cites W2079273552 @default.
• W1976335644 cites W2084568553 @default.
• W1976335644 cites W2084740377 @default.
• W1976335644 cites W2088580337 @default.
• W1976335644 cites W2091405353 @default.
• W1976335644 cites W2094655821 @default.
• W1976335644 cites W2095170053 @default.
• W1976335644 cites W2095318835 @default.
• W1976335644 cites W2099311438 @default.
• W1976335644 cites W2100250587 @default.
• W1976335644 cites W2106220546 @default.
• W1976335644 cites W2107860728 @default.
• W1976335644 cites W2127066215 @default.
• W1976335644 cites W2133682828 @default.
• W1976335644 cites W2142862239 @default.
• W1976335644 cites W2157364879 @default.
• W1976335644 cites W2162142628 @default.
• W1976335644 cites W2163250803 @default.
• W1976335644 cites W2285601132 @default.
• W1976335644 cites W4211147424 @default.
• W1976335644 cites W4256309416 @default.
• W1976335644 cites W4294961496 @default.
• W1976335644 cites W4321509025 @default.
• W1976335644 doi "https://doi.org/10.1038/mt.2014.78" @default.
• W1976335644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4435589" @default.
• W1976335644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24769909" @default.
• W1976335644 hasPublicationYear "2014" @default.
• W1976335644 type Work @default.
• W1976335644 sameAs 1976335644 @default.
• W1976335644 citedByCount "74" @default.
• W1976335644 countsByYear W19763356442014 @default.
• W1976335644 countsByYear W19763356442015 @default.
• W1976335644 countsByYear W19763356442016 @default.
• W1976335644 countsByYear W19763356442017 @default.
• W1976335644 countsByYear W19763356442018 @default.
• W1976335644 countsByYear W19763356442019 @default.
• W1976335644 countsByYear W19763356442020 @default.
• W1976335644 countsByYear W19763356442021 @default.
• W1976335644 countsByYear W19763356442022 @default.
• W1976335644 countsByYear W19763356442023 @default.
• W1976335644 crossrefType "journal-article" @default.
• W1976335644 hasAuthorship W1976335644A5001336137 @default.
• W1976335644 hasAuthorship W1976335644A5031287763 @default.
• W1976335644 hasAuthorship W1976335644A5047797435 @default.
• W1976335644 hasAuthorship W1976335644A5053275663 @default.
• W1976335644 hasAuthorship W1976335644A5055292026 @default.
• W1976335644 hasAuthorship W1976335644A5057019311 @default.
• W1976335644 hasBestOaLocation W19763356441 @default.
• W1976335644 hasConcept C105702510 @default.
• W1976335644 hasConcept C136229726 @default.
• W1976335644 hasConcept C151730666 @default.
• W1976335644 hasConcept C167734588 @default.
• W1976335644 hasConcept C171056886 @default.
• W1976335644 hasConcept C207200792 @default.
• W1976335644 hasConcept C2777025900 @default.
• W1976335644 hasConcept C2779343474 @default.
• W1976335644 hasConcept C2779959927 @default.
• W1976335644 hasConcept C2780394083 @default.
• W1976335644 hasConcept C502942594 @default.
• W1976335644 hasConcept C71924100 @default.
• W1976335644 hasConcept C86803240 @default.
• W1976335644 hasConcept C89429830 @default.
• W1976335644 hasConcept C95444343 @default.
• W1976335644 hasConceptScore W1976335644C105702510 @default.
• W1976335644 hasConceptScore W1976335644C136229726 @default.
• W1976335644 hasConceptScore W1976335644C151730666 @default.
• W1976335644 hasConceptScore W1976335644C167734588 @default.
• W1976335644 hasConceptScore W1976335644C171056886 @default.

• next