FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1976335995> ?p ?o ?g. }

• W1976335995 endingPage "595" @default.
• W1976335995 startingPage "588" @default.
• W1976335995 abstract "Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the response of neuronal ranscripts during the first 24 hr of a QA lesion within the rodent striatum. Following QA exposure, IEG mRNA induction periods extended from 30 min to 24 hr. Several characteristics of this prolonged transcriptional response suggest that separate cell populations (neuronal vs. glial) originate individual IEG phases during the first day of the lesion. The first IEG phase was rapid and peaked at 60 min. This initial IEG phase, likely neuronal in origin, was dominated by robust increases in the expression of c-fos, jun-B, and zif/268 mRNAs in contrast to small increases in c-jun expression. A second, delayed IEG phase was initiated after the first hour and extended to 24 hr. This IEG phase was more intense and continued beyond the period of neuronal survival as detected by the loss of neurotransmitter-specific mRNAs (preprotachykinin, preproenkephalin, and glutamic acid decarboxylase). During this phase, c-jun mRNA levels coordinately increased with c-fos. Interestingly, the transcriptional peak of the delayed IEG phase occurred between 4 and 12 hr, the time which corresponded to the rapid decline of neuronal transcripts. The temporal association of a delayed phase of IEG induction, possibly originating in nonneuronal cells, with neuronal death during the acute phases of the excitotoxic cascade suggest a link between glial IEG activation and the spreading cascade of neuronal damage characteristic of excitatory amino acid receptor overstimulation. © 1993 Wiley-Liss, Inc." @default.
• W1976335995 created "2016-06-24" @default.
• W1976335995 creator A5038165323 @default.
• W1976335995 creator A5055210348 @default.
• W1976335995 date "1993-12-01" @default.
• W1976335995 modified "2023-09-27" @default.
• W1976335995 title "Immediate early gene activation during the initial phases of the excitotoxic cascade" @default.
• W1976335995 cites W1483800737 @default.
• W1976335995 cites W1529166175 @default.
• W1976335995 cites W1892378391 @default.
• W1976335995 cites W1911312547 @default.
• W1976335995 cites W1958695407 @default.
• W1976335995 cites W1975404363 @default.
• W1976335995 cites W1976419173 @default.
• W1976335995 cites W1980435560 @default.
• W1976335995 cites W1984907601 @default.
• W1976335995 cites W1993855542 @default.
• W1976335995 cites W1994611219 @default.
• W1976335995 cites W1998279906 @default.
• W1976335995 cites W1998392208 @default.
• W1976335995 cites W2000447621 @default.
• W1976335995 cites W2002763309 @default.
• W1976335995 cites W2003102216 @default.
• W1976335995 cites W2005648670 @default.
• W1976335995 cites W2005657014 @default.
• W1976335995 cites W2006504264 @default.
• W1976335995 cites W2011776534 @default.
• W1976335995 cites W2015469236 @default.
• W1976335995 cites W2015772561 @default.
• W1976335995 cites W2016575029 @default.
• W1976335995 cites W2026660727 @default.
• W1976335995 cites W2026879846 @default.
• W1976335995 cites W2029112104 @default.
• W1976335995 cites W2029526969 @default.
• W1976335995 cites W2042569804 @default.
• W1976335995 cites W2043985651 @default.
• W1976335995 cites W2051353156 @default.
• W1976335995 cites W2051395367 @default.
• W1976335995 cites W2054187028 @default.
• W1976335995 cites W2055609099 @default.
• W1976335995 cites W2060645936 @default.
• W1976335995 cites W2062610641 @default.
• W1976335995 cites W2066631275 @default.
• W1976335995 cites W2069254216 @default.
• W1976335995 cites W2070747761 @default.
• W1976335995 cites W2071140879 @default.
• W1976335995 cites W2074431910 @default.
• W1976335995 cites W2074792377 @default.
• W1976335995 cites W2081304551 @default.
• W1976335995 cites W2085310064 @default.
• W1976335995 cites W2115736681 @default.
• W1976335995 cites W2125269304 @default.
• W1976335995 cites W2233662905 @default.
• W1976335995 cites W4294216491 @default.
• W1976335995 doi "https://doi.org/10.1002/jnr.490360511" @default.
• W1976335995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8145290" @default.
• W1976335995 hasPublicationYear "1993" @default.
• W1976335995 type Work @default.
• W1976335995 sameAs 1976335995 @default.
• W1976335995 citedByCount "25" @default.
• W1976335995 countsByYear W19763359952013 @default.
• W1976335995 countsByYear W19763359952020 @default.
• W1976335995 crossrefType "journal-article" @default.
• W1976335995 hasAuthorship W1976335995A5038165323 @default.
• W1976335995 hasAuthorship W1976335995A5055210348 @default.
• W1976335995 hasConcept C104317684 @default.
• W1976335995 hasConcept C150194340 @default.
• W1976335995 hasConcept C169760540 @default.
• W1976335995 hasConcept C170493617 @default.
• W1976335995 hasConcept C2776706248 @default.
• W1976335995 hasConcept C2777896816 @default.
• W1976335995 hasConcept C2778938600 @default.
• W1976335995 hasConcept C2779555244 @default.
• W1976335995 hasConcept C2780062018 @default.
• W1976335995 hasConcept C2780323455 @default.
• W1976335995 hasConcept C513476851 @default.
• W1976335995 hasConcept C515207424 @default.
• W1976335995 hasConcept C55493867 @default.
• W1976335995 hasConcept C61174792 @default.
• W1976335995 hasConcept C74254510 @default.
• W1976335995 hasConcept C86803240 @default.
• W1976335995 hasConceptScore W1976335995C104317684 @default.
• W1976335995 hasConceptScore W1976335995C150194340 @default.
• W1976335995 hasConceptScore W1976335995C169760540 @default.
• W1976335995 hasConceptScore W1976335995C170493617 @default.
• W1976335995 hasConceptScore W1976335995C2776706248 @default.
• W1976335995 hasConceptScore W1976335995C2777896816 @default.
• W1976335995 hasConceptScore W1976335995C2778938600 @default.
• W1976335995 hasConceptScore W1976335995C2779555244 @default.
• W1976335995 hasConceptScore W1976335995C2780062018 @default.
• W1976335995 hasConceptScore W1976335995C2780323455 @default.
• W1976335995 hasConceptScore W1976335995C513476851 @default.
• W1976335995 hasConceptScore W1976335995C515207424 @default.
• W1976335995 hasConceptScore W1976335995C55493867 @default.
• W1976335995 hasConceptScore W1976335995C61174792 @default.
• W1976335995 hasConceptScore W1976335995C74254510 @default.
• W1976335995 hasConceptScore W1976335995C86803240 @default.
• W1976335995 hasIssue "5" @default.

• next